{"id":"W4233393264","doi":"10.2139/ssrn.3608389","title":"Antibody Repertoire and Gene Expression Dynamics of Diverse Human B Cell States During Affinity Maturation","year":2020,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Ottawa Mental Health Centre","funders":"","keywords":"Repertoire; Antibody; Antibody Repertoire; Gene; Dynamics (music); Gene expression; Biology; Cell biology; Genetics; Computational biology; Molecular biology; Psychology; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009117548,0.00006639379,0.0001457137,0.000257002,0.00009987344,0.0003302761,0.00007591975,0.0001223539,0.00240635],"category_scores_gemma":[0.0002164159,0.0000863313,0.000121014,0.0002466756,0.0001095047,0.0001704965,0.0001280534,0.0001808792,0.0005344294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001217995,"about_ca_system_score_gemma":0.0000789012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005887409,"about_ca_topic_score_gemma":0.0004378039,"domain_scores_codex":[0.9999307,0.00001004617,0.000002915312,0.00001775446,0.0000113626,0.00002728766],"domain_scores_gemma":[0.9999168,0.00002897396,0.00001285888,0.000005227908,0.00002047758,0.00001566397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009316043,0.000027417,0.00900181,0.00001972961,0.00001224834,0.00006393492,0.0001730987,0.0001409386,0.9851347,0.0001459667,0.0000611362,0.004287434],"study_design_scores_gemma":[0.00004128727,0.0009457147,0.5522983,0.00001596068,0.00009004888,0.0006612732,0.0008764065,0.002728114,0.4386583,0.0004603988,0.003202126,0.00002198827],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988906,0.0002254171,0.0002093841,0.000008174516,0.000001550328,0.00000187847,0.0001270555,0.000006115544,0.0005298658],"genre_scores_gemma":[0.9983031,0.0001747139,0.0001254536,0.00001506393,0.000003759057,0.000007754948,0.000305416,0.00000650838,0.00105813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00240635,"threshold_uncertainty_score":0.008050084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01313983885854808,"score_gpt":0.2842966836193579,"score_spread":0.2711568447608099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}