{"id":"W4233431896","doi":"10.1042/0264-6021:3460063","title":"Activation of exocytosis by cross-linking of the IgE receptor is dependent on ADP-ribosylation factor 1-regulated phospholipase D in RBL-2H3 mast cells: evidence that the mechanism of activation is via regulation of phosphatidylinositol 4,5-bisphosphate synthesis","year":2000,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Institut Périmètre de physique théorique; Wellcome Trust","keywords":"Exocytosis; Phospholipase D; Phospholipase C; Phosphatidylethanol; Phosphatidic acid; Phosphatidylinositol; Cell biology; Secretion; Phospholipase; Mast cell; ADP ribosylation factor; Biology; Chemistry; Biochemistry; Signal transduction; Enzyme; Phospholipid; Golgi apparatus; Membrane; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002942967,0.0005515706,0.0004492446,0.0002121959,0.0002049688,0.0004277416,0.0002879993,0.0003943932,0.001005935],"category_scores_gemma":[0.00013369,0.0002398213,0.0006640668,0.0002142805,0.0002833296,0.0004628473,0.0003075369,0.0008619661,0.0005941834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005171431,"about_ca_system_score_gemma":0.0001773833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004518179,"about_ca_topic_score_gemma":0.0005402124,"domain_scores_codex":[0.9997644,0.00003734499,0.00003974921,0.00004307689,0.00006130313,0.00005413456],"domain_scores_gemma":[0.9998584,0.00003071679,0.0000368186,0.00003334986,0.00001125103,0.00002945167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009858792,0.000007728878,0.00006634666,0.000009789149,0.000001818779,0.00004244446,0.00000456681,0.00001656918,0.9995223,0.00002090167,0.000006591004,0.000202464],"study_design_scores_gemma":[0.00003476574,0.000124542,0.004636925,0.000002257245,0.00001068158,0.0002570287,0.00000925759,0.0006908939,0.9936689,0.00003053401,0.0005299581,0.000004456415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943066,0.001219871,0.002908767,0.0001909105,0.00002441067,0.00002756235,0.0006118972,0.0001262693,0.0005836695],"genre_scores_gemma":[0.9948866,0.0007927007,0.002436828,0.00007192847,0.00001529385,0.0000485488,0.0007661522,0.00003801267,0.0009438989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001005935,"threshold_uncertainty_score":0.003752172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01592823300596627,"score_gpt":0.2370363332430822,"score_spread":0.2211081002371159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}