{"id":"W4233451052","doi":"10.26434/chemrxiv.14390672","title":"Polycomb Paralog Chromodomain Inhibitors Active Against Both CBX6 and CBX8","year":2021,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Chromodomain; Polycomb-group proteins; PRC2; Chromatin; Histone H3; Biology; Genetics; Gene; Transcription factor; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001204718,0.0003328469,0.0002627464,0.0001913848,0.0001074851,0.0001897029,0.0002628323,0.0001873875,0.002943788],"category_scores_gemma":[0.00006798495,0.00008046295,0.0001368415,0.0001367201,0.0001294196,0.0001249876,0.0001290221,0.000496589,0.0006977431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002282375,"about_ca_system_score_gemma":0.0002104791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005007152,"about_ca_topic_score_gemma":0.001467072,"domain_scores_codex":[0.9999181,0.000008661886,0.000004838882,0.00001289771,0.00003732424,0.00001807978],"domain_scores_gemma":[0.999972,0.000005417268,0.00000547305,0.00000431941,0.000004573921,0.000008213483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002028381,0.00008934428,0.0001590765,0.0001019485,0.0000156749,0.00006102835,0.00001522771,0.000356261,0.9914519,0.0004697088,0.0005028531,0.006574184],"study_design_scores_gemma":[0.0000479591,0.0001958564,0.0005424353,0.000003012044,0.000007942781,0.00009662363,0.000004360802,0.0004659018,0.992092,0.00004257142,0.006498952,0.000002422101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9420413,0.0117706,0.01953062,0.000426632,0.0001926899,0.0003162196,0.003028442,0.0006285568,0.02206496],"genre_scores_gemma":[0.9478156,0.004282255,0.01244916,0.00009420822,0.00004205063,0.0001477627,0.002803627,0.00006903775,0.03229626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002943788,"threshold_uncertainty_score":0.009847939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007935516791895617,"score_gpt":0.2350584677956427,"score_spread":0.227122951003747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}