{"id":"W4233454438","doi":"10.1136/annrheumdis-2017-eular.6361","title":"SAT0195 Rituximab shows better sustainability than tnf inhibitors when used following initial biologic dmard failure in the treatment of rheumatoid arthritis: 8 years of real-world observations from the rhumadata® clinical database and registry","year":2017,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Osteoporosis Canada; Montreal Clinical Research Institute","funders":"Chugai Pharmaceutical","keywords":"Medicine; Discontinuation; Rheumatoid arthritis; Rituximab; Internal medicine; Ustekinumab; TNF inhibitor; Hazard ratio; Proportional hazards model; Adalimumab; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001118073,0.0001892578,0.0007015966,0.00003780225,0.0002697682,0.00003884775,0.0008256914,0.0001458595,0.00004300153],"category_scores_gemma":[0.002541039,0.00009612219,0.0004285469,0.00008421236,0.001678106,0.0001476303,0.0002623571,0.0001813944,8.395035e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001326584,"about_ca_system_score_gemma":0.0001128259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003408522,"about_ca_topic_score_gemma":0.002819567,"domain_scores_codex":[0.9972039,0.001281227,0.0008697605,0.0002967892,0.000105212,0.0002431242],"domain_scores_gemma":[0.9949117,0.002801459,0.000663086,0.001510176,0.00008164461,0.0000318813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003353306,0.001915181,0.9272188,0.00008494186,0.0007394775,0.000007216396,0.0009513408,6.443664e-7,0.0002742106,0.0007590852,0.005950247,0.06176354],"study_design_scores_gemma":[0.001913298,0.0002472035,0.9784853,0.0007351869,0.0001553014,0.000001415024,0.001441121,0.00000659604,0.001195177,0.01374286,0.001938445,0.0001381377],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857984,0.003086351,0.000006972093,0.008827982,0.0002053214,0.0005273813,0.001520424,0.000007983944,0.00001925256],"genre_scores_gemma":[0.9962276,0.003080143,0.0002337978,0.0002607387,0.0000228484,0.00002942525,0.0001140986,0.000008163747,0.00002325096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06162541,"threshold_uncertainty_score":0.618305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1140965422149544,"score_gpt":0.3833881961012979,"score_spread":0.2692916538863436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}