{"id":"W4233455462","doi":"10.1172/jci0215748","title":"Increased ABCA1 activity protects against atherosclerosis","year":2002,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":221,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; Xenon Pharmaceuticals (Canada); Children's & Women's Health Centre of British Columbia; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"ABCA1; Efflux; Cholesterol; Reverse cholesterol transport; Apolipoprotein E; Genetically modified mouse; Phospholipid; Transgene; Chemistry; Transporter; In vivo; Biology; Endocrinology; Lipoprotein; Internal medicine; Biochemistry; Medicine; Gene; Membrane; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003211771,0.0004484071,0.001065796,0.0004362385,0.0002101408,0.0004743743,0.0003086272,0.0005444865,0.003563857],"category_scores_gemma":[0.0003698302,0.0002643001,0.0003001862,0.0002461782,0.0003241891,0.0002777861,0.0002839018,0.001681349,0.0008560809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001938237,"about_ca_system_score_gemma":0.0002324977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003988612,"about_ca_topic_score_gemma":0.0003439455,"domain_scores_codex":[0.9997569,0.00005646024,0.00002317132,0.00003187303,0.00004937293,0.00008231495],"domain_scores_gemma":[0.9995503,0.00005522199,0.00008613464,0.00009629002,0.00005430066,0.0001577352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003893535,0.001145496,0.0009524403,0.0001424721,0.0000905207,0.0001738965,0.00003101464,0.0001185178,0.9759493,0.00035556,0.0009202716,0.01622704],"study_design_scores_gemma":[0.002333106,0.03155331,0.05406248,0.0001009091,0.000557764,0.002264824,0.0001475709,0.002028474,0.8838915,0.001046728,0.02194857,0.00006495329],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921441,0.003913729,0.0009249765,0.000531721,0.0001764309,0.00002596746,0.0002943673,0.0002879328,0.001700815],"genre_scores_gemma":[0.9925052,0.002227918,0.0004450203,0.0002478665,0.0001095788,0.00004111381,0.0007472191,0.0000363438,0.003639713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003563857,"threshold_uncertainty_score":0.01192224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1444098704158182,"score_gpt":0.3598064876084234,"score_spread":0.2153966171926052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}