{"id":"W4233455462","doi":"10.1172/jci0215748","title":"Increased ABCA1 activity protects against atherosclerosis","year":2002,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":221,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; Xenon Pharmaceuticals (Canada); Children's & Women's Health Centre of British Columbia; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"ABCA1; Efflux; Cholesterol; Reverse cholesterol transport; Apolipoprotein E; Genetically modified mouse; Phospholipid; Transgene; Chemistry; Transporter; In vivo; Biology; Endocrinology; Lipoprotein; Internal medicine; Biochemistry; Medicine; Gene; Membrane; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001577743,0.0001239775,0.0005878485,0.0001016989,0.00004920561,0.0000273363,0.00009246725,0.0001929586,0.00008776488],"category_scores_gemma":[0.00305208,0.00009128647,0.0003303599,0.0001952744,0.0001656629,0.0002821424,0.00001893435,0.0007299435,0.0000476965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003078116,"about_ca_system_score_gemma":0.00009744422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000862315,"about_ca_topic_score_gemma":0.000001630385,"domain_scores_codex":[0.9979137,0.0002841503,0.001052976,0.0001487151,0.0004511077,0.0001493803],"domain_scores_gemma":[0.9978063,0.0002673888,0.0009478368,0.0002061588,0.0002797978,0.0004925731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0008676322,0.00205871,0.2684181,0.0002056659,0.0003572977,0.00005560855,0.0007019369,0.00003207936,0.3470549,0.0001008145,0.01220715,0.3679401],"study_design_scores_gemma":[0.004399468,0.0006648696,0.967329,0.0003783552,0.0001358625,0.00004680568,0.00001382962,0.001577649,0.01437376,0.0002651513,0.01070478,0.0001105142],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942603,0.0001091112,0.0001515945,0.003999922,0.0005692419,0.0002185196,0.000001502825,0.00002182463,0.0006680079],"genre_scores_gemma":[0.9918452,0.0002926098,0.0023063,0.003139143,0.002130045,0.000003547138,0.000001321376,0.00001702438,0.0002648115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6989108,"threshold_uncertainty_score":0.3722554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1444098704158182,"score_gpt":0.3598064876084234,"score_spread":0.2153966171926052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}