{"id":"W4233599027","doi":"10.1002/9780470015902.a0029286","title":"Functional Constraint and Molecular Evolution","year":2021,"lang":"en","type":"other","venue":"Encyclopedia of Life Sciences","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Phenotype; Genome; Nucleic acid; Biology; Natural selection; Computational biology; Genetics; Gene; Function (biology); Directed Molecular Evolution; Oligonucleotide; Selection (genetic algorithm); Directed evolution; Mutant; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002078559,0.0003824025,0.0004879361,0.001207279,0.001220522,0.00181855,0.0008765666,0.001440114,0.008740809],"category_scores_gemma":[0.00431627,0.0001650591,0.0003898818,0.0009365767,0.008913173,0.002483732,0.001854773,0.001552201,0.0006360154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002365028,"about_ca_system_score_gemma":0.0006668144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001593727,"about_ca_topic_score_gemma":0.0008896967,"domain_scores_codex":[0.9985167,0.0007020482,0.00007127017,0.0003126153,0.0002589202,0.0001384279],"domain_scores_gemma":[0.9980317,0.001064869,0.0002465839,0.0002260209,0.000318957,0.0001118325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00001123799,0.000004906833,0.0007881784,0.0000545381,0.00001627805,0.0001073015,0.0001580913,0.001796855,0.0005475784,0.9809869,0.001209083,0.01431903],"study_design_scores_gemma":[0.00001215187,0.00002347925,0.001506988,0.00003512393,0.000009647405,0.0003216893,0.0001419582,0.003903936,0.0003441863,0.9548567,0.03882721,0.00001706591],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.212931,0.02619031,0.1358839,0.05501464,0.001222815,0.0001142454,0.000443391,0.0002508401,0.5679488],"genre_scores_gemma":[0.9513735,0.003888231,0.01867175,0.002444825,0.0004528035,0.000104429,0.0002008753,0.00006512219,0.02279846],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.008740809,"threshold_uncertainty_score":0.02924091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01180455923857218,"score_gpt":0.235330478643033,"score_spread":0.2235259194044608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}