{"id":"W4233660921","doi":"10.1201/b18768-24","title":"Epigenomic Mechanisms of Early Adversity and HPA Dysfunction: Considerations for PTSD Research","year":2015,"lang":"en","type":"book-chapter","venue":"Apple Academic Press eBooks","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Scarborough Hospital; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Psychology; Epigenomics; Clinical psychology; Biology; Genetics; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002927162,0.0002858361,0.0004348786,0.0002091252,0.0003356532,0.00003917533,0.0003759086,0.0006597975,0.00005644264],"category_scores_gemma":[0.0004378908,0.0002973066,0.0001129868,0.00001265725,0.0005098604,0.00008906712,0.0004522435,0.001066961,0.00001430635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007694201,"about_ca_system_score_gemma":0.0002840606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001300208,"about_ca_topic_score_gemma":0.00001548261,"domain_scores_codex":[0.9976498,0.0001098959,0.0004718727,0.0007372724,0.0006237029,0.0004074084],"domain_scores_gemma":[0.9972785,0.001505511,0.0002986867,0.0004685378,0.0002433852,0.0002054176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004998095,0.000007781044,0.000001771116,0.00009223678,0.00003335314,0.00001493358,0.0004988893,0.000004391925,0.05125521,0.933663,0.009202339,0.004726306],"study_design_scores_gemma":[0.00134007,0.0005409911,0.000007607127,0.0001634825,0.0001241527,0.00006533207,0.00008680025,0.0001052879,0.1284931,0.563615,0.3049596,0.0004985793],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.01115247,0.005433759,0.009462327,0.0004662104,0.001410222,0.01028038,0.005635635,0.0003971422,0.9557618],"genre_scores_gemma":[0.2611979,0.001709184,0.0005142845,0.0002823434,0.0004007639,0.0004322169,0.00002083585,0.0001468837,0.7352956],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.370048,"threshold_uncertainty_score":0.9999479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2745058324762839,"score_gpt":0.3571052232264474,"score_spread":0.08259939075016359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}