{"id":"W4233676300","doi":"10.1002/ange.201809928","title":"Facile Formation of β‐thioGlcNAc Linkages to Thiol‐Containing Sugars, Peptides, and Proteins using a Mutant GH20 Hexosaminidase","year":2018,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Glycomics Network; Canadian Institutes of Health Research; Austrian Science Fund","keywords":"Chemistry; Biochemistry; Thiol; Cysteine; Enzyme; Alanine; Mutant; Amino acid; Thio-; Glycoside hydrolase; Hydrolase; Stereochemistry; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002092043,0.0002642325,0.0003592037,0.00006083935,0.0001627772,0.00005669426,0.000182356,0.0002058988,0.0004549866],"category_scores_gemma":[0.0002754964,0.000259107,0.00009609644,0.0001844244,0.0001432829,0.0002160793,0.0001743567,0.0001637539,0.00001016818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009562644,"about_ca_system_score_gemma":0.00006078857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000128876,"about_ca_topic_score_gemma":0.00003450239,"domain_scores_codex":[0.9986072,0.0000118073,0.000422734,0.0003655647,0.0002373268,0.0003553951],"domain_scores_gemma":[0.9989494,0.0001003946,0.000199957,0.0003988981,0.0001638,0.0001875179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006399102,0.00003879466,0.0005909565,0.00036336,0.00003376603,0.0000122553,0.002119129,0.000001451417,0.9957373,0.000008865025,0.0001035427,0.0009266408],"study_design_scores_gemma":[0.0003886084,0.00005583138,0.00004364879,0.0003391774,0.0000571399,0.00004286158,0.001417983,0.0001779479,0.9953914,0.00007017661,0.001710232,0.0003049389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987097,0.0001277205,0.0001171644,0.0000933621,0.00003030282,0.0001387957,0.0001218393,0.00007688982,0.01219687],"genre_scores_gemma":[0.9973721,0.00003183191,0.001771065,0.00007786366,0.0003135222,0.00003256293,0.0000612883,0.00003007169,0.0003096882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01188718,"threshold_uncertainty_score":0.9999861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03006419994510546,"score_gpt":0.2570372722972647,"score_spread":0.2269730723521592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}