{"id":"W4233752323","doi":"10.1212/nxi.0000000000000276","title":"Restoring immune tolerance in neuromyelitis optica","year":2016,"lang":"en","type":"review","venue":"Neurology Neuroimmunology & Neuroinflammation","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Guthy-Jackson Charitable Foundation","keywords":"Neuromyelitis optica; Medicine; Immune system; Immune tolerance; Immunology; Disease; Neuroscience; Bioinformatics; Multiple sclerosis; Psychology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0005636913,0.001288347,0.004410936,0.001895911,0.0002631149,0.00005076953,0.000906292,0.001145138,0.0001555441],"category_scores_gemma":[0.003428774,0.001048721,0.0009086432,0.001081417,0.0008227755,0.0003217135,0.0008510125,0.003781795,0.0009361897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002085956,"about_ca_system_score_gemma":0.0005083262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002722374,"about_ca_topic_score_gemma":0.00001502831,"domain_scores_codex":[0.9908762,0.002124059,0.002552497,0.002085347,0.0006794621,0.001682426],"domain_scores_gemma":[0.9939773,0.002244306,0.0009854579,0.002353985,0.0002242316,0.0002146925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005386444,0.0001597483,0.0001514496,0.004461573,0.0001491299,0.002972436,0.00004983339,0.000007335541,0.003284876,0.0001951197,0.0001321542,0.9878977],"study_design_scores_gemma":[0.00233896,0.00124607,0.04668204,0.005428137,0.0002664817,0.002890826,0.000001861828,0.00005320118,0.00004410743,0.0000353283,0.9403883,0.0006246548],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01426265,0.9739704,0.000006721662,0.003750687,0.002087879,0.003493665,0.00004673336,0.0004589273,0.00192231],"genre_scores_gemma":[0.001052385,0.9964741,0.00004378275,0.0002706614,0.0005763353,0.0007255083,0.00009928124,0.0003000358,0.0004579128],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.987273,"threshold_uncertainty_score":0.9999868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06079188881984954,"score_gpt":0.3480146735541715,"score_spread":0.2872227847343219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}