{"id":"W4233761810","doi":"10.1016/s0009-2797(02)00185-0","title":"Modulating carbonyl cytotoxicity in intact rat hepatocytes by inhibiting carbonyl-metabolizing enzymes. I. Aliphatic alkenals","year":2003,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Alcohol Consumption and Health Effects","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Canada; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Health Canada","keywords":"Acrolein; Cytotoxicity; Biochemistry; Glutathione; Chemistry; Aldehyde dehydrogenase; NAD+ kinase; Lipid peroxidation; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005448098,0.0003459954,0.0007048208,0.0001853937,0.0001906939,0.00004551771,0.0001033587,0.0002619601,0.0006543084],"category_scores_gemma":[0.0023242,0.0002901075,0.000196355,0.0003731265,0.000125277,0.0001797833,0.00006435348,0.0009942597,0.00006706942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004448613,"about_ca_system_score_gemma":0.0001013923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001791799,"about_ca_topic_score_gemma":0.00002862489,"domain_scores_codex":[0.9975097,0.0002495523,0.0008185428,0.0005854612,0.0001952949,0.0006414387],"domain_scores_gemma":[0.998217,0.0008213304,0.0002617516,0.000261173,0.000112184,0.0003265445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006781869,0.0002793284,0.07878774,0.00009630642,0.00004160561,0.00003138984,0.0002319781,0.00001204376,0.9186546,0.0005682406,0.0006813175,0.0005475994],"study_design_scores_gemma":[0.002179107,0.0001677944,0.008168667,0.000714075,0.00007416822,0.000300965,0.0006872232,0.003372359,0.9782609,0.0002659539,0.005264176,0.0005445605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895107,0.001514967,0.0001371254,0.0004577365,0.0003017247,0.0007052709,0.00001117184,0.0001817588,0.007179512],"genre_scores_gemma":[0.9964287,0.0002056395,0.0007039258,0.001977146,0.0001467899,0.0001852186,0.00008741127,0.00003097405,0.0002342554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07061907,"threshold_uncertainty_score":0.9999551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1078932952536289,"score_gpt":0.377127023450096,"score_spread":0.2692337281964671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}