{"id":"W4233779081","doi":"10.1158/1078-0432.ccr-15-2119","title":"Cotargeting Androgen Receptor Splice Variants and mTOR Signaling Pathway for the Treatment of Castration-Resistant Prostate Cancer","year":2015,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute; U.S. Department of Defense","keywords":"Enzalutamide; PI3K/AKT/mTOR pathway; Prostate cancer; Androgen receptor; Protein kinase B; Cancer research; Everolimus; Cancer; Biology; Medicine; Pharmacology; Signal transduction; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001570098,0.0004491596,0.0004139912,0.0002372527,0.0001316678,0.0002902032,0.0003163271,0.0001957583,0.001178333],"category_scores_gemma":[0.00005105958,0.0001185843,0.0003055886,0.0002236227,0.0002127108,0.0001769073,0.0001389289,0.0007101998,0.0002608991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002968705,"about_ca_system_score_gemma":0.0004005548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001025589,"about_ca_topic_score_gemma":0.002879921,"domain_scores_codex":[0.9998817,0.0000194736,0.00001106907,0.00002274251,0.0000394403,0.00002548396],"domain_scores_gemma":[0.9999652,0.000004031639,0.00000892431,0.000004334202,0.000003901804,0.000013609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006405936,0.0004966075,0.0002831299,0.0001051805,0.00003551591,0.00006698329,0.00001715316,0.0004577647,0.9901794,0.0001881749,0.0001771036,0.007352443],"study_design_scores_gemma":[0.0004059486,0.01153345,0.005335201,0.00001250482,0.0001457211,0.0007482684,0.00003615699,0.00200748,0.9722605,0.00004408183,0.007454241,0.00001641253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926634,0.00308624,0.001348949,0.0001183947,0.0000710585,0.0001274058,0.0003446589,0.0001287691,0.002111156],"genre_scores_gemma":[0.9932182,0.001911267,0.002013993,0.00007353562,0.00001973835,0.00007809416,0.0005532661,0.00001384161,0.002118004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001178333,"threshold_uncertainty_score":0.003941894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3324940879289064,"score_gpt":0.5156486817377322,"score_spread":0.1831545938088258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}