{"id":"W4234317413","doi":"10.1146/annurev.biochem.71.110601.135414","title":"Lipopolysaccharide Endotoxins","year":2002,"lang":"en","type":"review","venue":"Annual Review of Biochemistry","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":4315,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Institute of General Medical Sciences","keywords":"Lipid A; Biology; TLR4; Lipopolysaccharide; Innate immune system; Bacterial outer membrane; Receptor; Cell biology; Signal transduction; Biochemistry; Periplasmic space; Lipid signaling; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029083,0.001383902,0.0009965929,0.001104007,0.0004663884,0.001177786,0.0007460361,0.001358089,0.008382514],"category_scores_gemma":[0.0003477873,0.0001670943,0.0002867937,0.001001548,0.0005988796,0.0008739037,0.0009650242,0.001376669,0.01479339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007426062,"about_ca_system_score_gemma":0.0006799984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005431452,"about_ca_topic_score_gemma":0.0004844589,"domain_scores_codex":[0.9997796,0.00004276336,0.00002133653,0.00003679351,0.00008477868,0.00003475423],"domain_scores_gemma":[0.999886,0.00001515715,0.00001904854,0.000008304659,0.00003479561,0.00003661135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002429188,0.000131348,0.0004831535,0.005079768,0.00006272992,0.0009891426,0.0001176608,0.0003829704,0.03347852,0.01681865,0.07999954,0.8622135],"study_design_scores_gemma":[0.00001256749,0.00005873754,0.0003227002,0.0003448974,0.00001079182,0.001249915,0.00002963373,0.00002414969,0.003171336,0.00168749,0.9930796,0.000008159967],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002011081,0.9651828,0.002527149,0.00126519,0.00374374,0.00006754711,0.0001918807,0.000149428,0.02486126],"genre_scores_gemma":[0.01955822,0.9193063,0.003421216,0.002709755,0.001448478,0.0001123465,0.0009371353,0.00002829625,0.0524781],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008382514,"threshold_uncertainty_score":0.02804238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01747309189058292,"score_gpt":0.3006004416362896,"score_spread":0.2831273497457066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}