{"id":"W4234490380","doi":"10.1128/aac.00279-17","title":"A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of an Anti-Influenza B Virus Monoclonal Antibody, MHAB5553A, in Healthy Volunteers","year":2017,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"inVentiv Health Clinical","funders":"Genentech","keywords":"Tolerability; Pharmacokinetics; Medicine; Placebo; Adverse effect; Internal medicine; Dosing; Gastroenterology; Pharmacology; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002414306,0.002206453,0.003042322,0.0004880162,0.000731079,0.0007919,0.001097437,0.002201643,0.005171792],"category_scores_gemma":[0.001928979,0.001032975,0.001074769,0.0003096992,0.001447583,0.00107582,0.0002830089,0.002316267,0.001094864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000597552,"about_ca_system_score_gemma":0.001607138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006951794,"about_ca_topic_score_gemma":0.001453508,"domain_scores_codex":[0.9993092,0.0003066758,0.00004100249,0.0001492744,0.00006948347,0.0001244372],"domain_scores_gemma":[0.9987643,0.0003384638,0.0002453203,0.0001072123,0.0001327923,0.000412056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9296207,0.03888182,0.0007098729,0.0005435901,0.000354939,0.00006344179,0.00008093491,0.0002776213,0.01675359,0.00009989402,0.001018321,0.01159534],"study_design_scores_gemma":[0.7987809,0.1976805,0.001480113,0.00001727842,0.000158815,0.00002385049,0.00001456909,0.0003078671,0.0009915706,0.00007569198,0.000452931,0.00001601961],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829872,0.001952068,0.001118967,0.0005135107,0.0006830557,0.01011764,0.001073645,0.0001594535,0.001394585],"genre_scores_gemma":[0.9709471,0.002209191,0.003766844,0.002387731,0.000943328,0.01296928,0.001358784,0.00004703771,0.005370717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005171792,"threshold_uncertainty_score":0.01730144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09828545564609437,"score_gpt":0.4346217277978595,"score_spread":0.3363362721517651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}