{"id":"W4234581092","doi":"10.1158/1538-7445.am2014-659","title":"Abstract 659: Integrated therapeutic antibody development at the National Research Council of Canada","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Antibody; Biomanufacturing; Antibody Repertoire; Monoclonal antibody; Computational biology; Medicine; Immunology; Biology; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005249137,0.0008500338,0.0005329946,0.001844194,0.002125325,0.002111621,0.002378956,0.001366705,0.04431271],"category_scores_gemma":[0.002059163,0.0005352821,0.0004430229,0.00115487,0.0007781813,0.0004956224,0.001557057,0.001658442,0.01572333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.02149976,"about_ca_system_score_gemma":0.08068743,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.6327508,"about_ca_topic_score_gemma":0.6676474,"domain_scores_codex":[0.9956755,0.0002946189,0.00008072057,0.0002986193,0.002965303,0.0006852378],"domain_scores_gemma":[0.9912367,0.0001681419,0.0001544202,0.000212008,0.005997433,0.002231307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009347429,0.0007387714,0.004760794,0.0004893639,0.00006355118,0.0006731725,0.0003165921,0.002446069,0.1107447,0.01986726,0.6347209,0.2242441],"study_design_scores_gemma":[0.0001674255,0.0003572666,0.005051717,0.00007687474,0.00002350307,0.0001795183,0.00008320525,0.002219385,0.01482952,0.0004949085,0.9764786,0.0000380085],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"methods","genre_scores_codex":[0.05328414,0.02210925,0.07406937,0.0392016,0.00538469,0.00647561,0.02965792,0.01053724,0.7592802],"genre_scores_gemma":[0.1143641,0.01140246,0.07865735,0.006085066,0.0003748977,0.00132211,0.02680012,0.000900063,0.7600939],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.6327508,"threshold_uncertainty_score":0.738824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2873247147004515,"score_gpt":0.4637272266095531,"score_spread":0.1764025119091017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}