{"id":"W4234696818","doi":"10.3410/f.732647410.793546173","title":"Faculty Opinions recommendation of MEK drives BRAF activation through allosteric control of KSR proteins.","year":2018,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs","keywords":"Allosteric regulation; Kinase; Gene isoform; GTP'; Chemistry; Enzyme; Cell biology; Enzyme activator; Protein kinase domain; Domain (mathematical analysis); Computational biology; Biochemistry; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005356113,0.001209266,0.0007682523,0.002072852,0.0004442211,0.001305773,0.001443979,0.000910435,0.03893565],"category_scores_gemma":[0.003584047,0.0002601629,0.0009983268,0.003259116,0.0002088088,0.0006729519,0.0007465507,0.0009755791,0.02884019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001085102,"about_ca_system_score_gemma":0.00172103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01542107,"about_ca_topic_score_gemma":0.0383176,"domain_scores_codex":[0.9993673,0.00008501131,0.00006866617,0.0002390339,0.0001589534,0.00008113074],"domain_scores_gemma":[0.9988396,0.0003862987,0.000223327,0.0001678058,0.0002303769,0.0001525414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004066742,0.00005292715,0.01893072,0.004475868,0.0004005293,0.0001454084,0.00006422565,0.001126001,0.001323878,0.0009247537,0.9571576,0.01499143],"study_design_scores_gemma":[0.0003156876,0.00004192578,0.02636271,0.0003907069,0.0002083064,0.0001671663,0.00006718257,0.001108159,0.001699635,0.0007077861,0.9689065,0.00002425074],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.001771068,0.000429405,0.00009509063,0.0001605175,0.00003179016,0.00001221495,0.9951187,0.0004177658,0.001963275],"genre_scores_gemma":[0.003859848,0.0002695089,0.0003723132,0.00005574763,0.00001110809,0.00003848147,0.9943069,0.00005965945,0.001026443],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.03893565,"threshold_uncertainty_score":0.1302527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0243919063520658,"score_gpt":0.3275674375734764,"score_spread":0.3031755312214107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}