{"id":"W4234702985","doi":"10.1002/ange.201408015","title":"Coumarin‐Based Fluorogenic Probes for No‐Wash Protein Labeling","year":2014,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Maleimide; Fluorophore; Chemistry; Reactivity (psychology); Thiol; Fluorescence; Peptide; Reagent; Combinatorial chemistry; Coumarin; Intracellular; Dithiol; Glutathione; Bioorthogonal chemistry; Cysteine; Biochemistry; Organic chemistry; Click chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000146118,0.0002228429,0.0002192567,0.00001495898,0.0001939862,0.00004995664,0.0003007749,0.0001818777,0.0007927115],"category_scores_gemma":[0.0002316838,0.0002267474,0.000158248,0.00009380464,0.00006796849,0.00005206401,0.00005334606,0.000162939,0.00008969429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005694711,"about_ca_system_score_gemma":0.00006085516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000106854,"about_ca_topic_score_gemma":0.000004541585,"domain_scores_codex":[0.9987954,0.000004071666,0.0002674253,0.0004229294,0.0001551939,0.0003549465],"domain_scores_gemma":[0.9989083,0.0001414197,0.0001192516,0.0005410974,0.0001604781,0.0001294172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003089614,0.0001090582,0.0001351202,0.0004823393,0.00002547345,3.313808e-7,0.00001930323,0.000006014588,0.9948323,0.0001771492,0.003363698,0.0008183389],"study_design_scores_gemma":[0.0008189615,0.00001199173,0.000002520551,0.00008521907,0.00003525936,0.00000160705,0.00001302082,0.0002911863,0.8214449,0.0004827899,0.1765728,0.0002397419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9236833,0.0001950773,0.001054942,0.000819017,0.00004304859,0.0005163648,0.0001614554,0.0004503748,0.0730764],"genre_scores_gemma":[0.9784214,0.000005734218,0.004694021,0.0002361416,0.0006975899,0.001341904,0.0004745176,0.00005727474,0.01407135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1733873,"threshold_uncertainty_score":0.9246489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01796576950074885,"score_gpt":0.2495506775268012,"score_spread":0.2315849080260523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}