{"id":"W4234744557","doi":"10.1038/npre.2009.3419","title":"Technical Note: The Use of RNA-interference as a Tool to Find Proteins Involved in Melanosome Formation or Transport","year":2009,"lang":"en","type":"preprint","venue":"Nature Precedings","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Cancer Institute; Hospital for Sick Children","keywords":"Melanosome; Gene knockdown; Cell biology; RNA interference; Biology; Tyrosinase; Melanocyte; Melanin; Chemistry; Gene; RNA; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01022747,0.002131165,0.001853558,0.002187318,0.001893164,0.001400933,0.001629436,0.002097826,0.03457688],"category_scores_gemma":[0.008615536,0.001670825,0.002901561,0.001236127,0.001915918,0.001550835,0.002834827,0.003880733,0.03574146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005252293,"about_ca_system_score_gemma":0.002045185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006749649,"about_ca_topic_score_gemma":0.0017028,"domain_scores_codex":[0.9896087,0.002590488,0.00160065,0.001598557,0.003971349,0.0006303159],"domain_scores_gemma":[0.9859201,0.004680619,0.0009327228,0.003922279,0.003573153,0.0009711009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005750136,0.0004067053,0.001016363,0.001410783,0.0001089623,0.001192771,0.0005346665,0.0002565357,0.9289088,0.002987233,0.02429224,0.03830995],"study_design_scores_gemma":[0.0004624245,0.001430881,0.004885466,0.0002656609,0.0003474561,0.01198273,0.0001839133,0.002154404,0.5717289,0.001656818,0.4047277,0.0001735685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.07038812,0.01319734,0.8056158,0.01377936,0.01955927,0.01967905,0.009307189,0.01598055,0.03249331],"genre_scores_gemma":[0.112703,0.01310475,0.6872011,0.005011934,0.002978886,0.02620421,0.02137233,0.005491084,0.1259326],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.03457688,"threshold_uncertainty_score":0.1156712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02466549615650596,"score_gpt":0.2972212111207946,"score_spread":0.2725557149642887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}