{"id":"W4234779896","doi":"10.31234/osf.io/cr69u","title":"Association between polygenic risk for Alzheimer’s disease, brain structure and cognitive abilities in UK Biobank.","year":2021,"lang":"en","type":"preprint","venue":"","topic":"Health, Environment, Cognitive Aging","field":"Environmental Science","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Northwest Regional Development Agency; British Heart Foundation; Wellcome Trust","keywords":"Apolipoprotein E; Effects of sleep deprivation on cognitive performance; Biobank; Confounding; Medicine; Internal medicine; Cognition; Dementia; Psychology; Hippocampal formation; Body mass index; Neuroimaging; Oncology; Gerontology; Demography; Disease; Psychiatry; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001026487,0.0004136506,0.0004914873,0.00009117211,0.0001860914,0.0001198819,0.0001968206,0.0004321869,0.001762075],"category_scores_gemma":[0.001415277,0.0004341133,0.0001393321,0.0001455197,0.0002031028,0.0001863044,0.000937545,0.000801203,0.00002278932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008246043,"about_ca_system_score_gemma":0.0001057345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003268118,"about_ca_topic_score_gemma":0.00349437,"domain_scores_codex":[0.9964711,0.0005257875,0.0005154687,0.001381976,0.0004906947,0.0006149553],"domain_scores_gemma":[0.997229,0.001697381,0.0004116729,0.0003533008,0.00001548015,0.0002931155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002166662,0.00002891772,0.9791692,0.00004973133,0.0001824798,0.00000301607,0.0009382337,0.00008691817,0.00003984952,0.000003327085,0.0002298871,0.01924674],"study_design_scores_gemma":[0.0006331856,0.00003255284,0.9913567,0.0001144157,0.0005289234,3.236588e-7,0.0008450379,0.0003812202,0.0003811875,0.005007335,0.0002427143,0.000476438],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906245,0.0008967159,0.001513627,0.001733443,0.0001432359,0.00205988,0.002452378,0.00004100451,0.0005352148],"genre_scores_gemma":[0.9962549,0.000316434,0.001084724,0.0008105388,0.0001261626,0.0002020855,0.0008085488,0.0000464471,0.0003502009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0187703,"threshold_uncertainty_score":0.9998111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01988868211226473,"score_gpt":0.2807744985975681,"score_spread":0.2608858164853034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}