{"id":"W4234779896","doi":"10.31234/osf.io/cr69u","title":"Association between polygenic risk for Alzheimer’s disease, brain structure and cognitive abilities in UK Biobank.","year":2021,"lang":"en","type":"preprint","venue":"","topic":"Health, Environment, Cognitive Aging","field":"Environmental Science","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Northwest Regional Development Agency; British Heart Foundation; Wellcome Trust","keywords":"Apolipoprotein E; Effects of sleep deprivation on cognitive performance; Biobank; Confounding; Medicine; Internal medicine; Cognition; Dementia; Psychology; Hippocampal formation; Body mass index; Neuroimaging; Oncology; Gerontology; Demography; Disease; Psychiatry; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00165515,0.0002722288,0.000452065,0.001154026,0.0004302662,0.0005634043,0.0004772318,0.0006581537,0.003055929],"category_scores_gemma":[0.008398491,0.0002887044,0.0003713463,0.002531881,0.0003568211,0.000574235,0.001103795,0.0004591573,0.0005140072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006644137,"about_ca_system_score_gemma":0.0003721318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.05336564,"about_ca_topic_score_gemma":0.05659808,"domain_scores_codex":[0.9986137,0.0004971406,0.0002349796,0.0003634366,0.000189785,0.0001009356],"domain_scores_gemma":[0.9943937,0.0009760394,0.003026364,0.0008257609,0.0004647214,0.0003134426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001968421,0.00002289205,0.9955496,0.00005742066,0.0001569009,0.0001093495,0.0002098012,0.00006099314,0.0003050698,0.00006046777,0.001077429,0.002193267],"study_design_scores_gemma":[0.00000987284,0.00001909326,0.9993312,0.00001143379,0.00002906162,0.0001207088,0.00003253813,0.00004893307,0.0000272245,0.00002211378,0.0003451296,0.000002728081],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854314,0.0006520033,0.0003347496,0.0002007209,0.00001069271,0.00003295981,0.01255453,0.00001473925,0.0007681542],"genre_scores_gemma":[0.9904883,0.0002033344,0.0005184968,0.0001097414,0.00001208919,0.00008370405,0.007962095,0.000007688983,0.0006144684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05336564,"threshold_uncertainty_score":0.10611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01988868211226473,"score_gpt":0.2807744985975681,"score_spread":0.2608858164853034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}