{"id":"W4234875829","doi":"10.21203/rs.3.rs-20854/v1","title":"Sirt3 Regulates Radioresistance of Non-small Cell Lung Cancer through ATM-Chk2 Pathway","year":2020,"lang":"en","type":"preprint","venue":"Research Square (Research Square)","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Miller Group (Canada)","funders":"National Natural Science Foundation of China; Shanghai Association for Science and Technology","keywords":"Radioresistance; Cancer research; Cancer; Cell biology; Medicine; Biology; Internal medicine; Radiation therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","open_science","research_integrity"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.007783614,0.001315653,0.001685577,0.001258158,0.0009458268,0.0005221615,0.004864868,0.002565789,0.0006629016],"category_scores_gemma":[0.002539913,0.0013746,0.001166994,0.003018845,0.001922094,0.00003803542,0.009667126,0.008438876,0.0001294833],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001348936,"about_ca_system_score_gemma":0.0100967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004460121,"about_ca_topic_score_gemma":0.001102344,"domain_scores_codex":[0.9781126,0.00450493,0.001634526,0.004235122,0.007101704,0.004411117],"domain_scores_gemma":[0.9856609,0.0007906985,0.0005125576,0.004641171,0.006989984,0.001404738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001978965,0.0007531822,0.000339785,0.01152714,0.0008002127,0.0003898392,0.001470802,0.003742764,0.9143653,0.0005759354,0.06091581,0.003140251],"study_design_scores_gemma":[0.002354718,0.002089559,0.0005136352,0.002912821,0.00006954747,0.00001100463,0.001036874,0.004681887,0.931537,0.002440078,0.05096789,0.001384935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6913051,0.1858169,0.05051757,0.00918505,0.002322527,0.029072,0.006678989,0.0004329731,0.02466897],"genre_scores_gemma":[0.9513298,0.03174808,0.00298147,0.0001106979,0.002162136,0.003443871,0.001640163,0.0006581694,0.005925595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2600247,"threshold_uncertainty_score":0.9999595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05169680502484657,"score_gpt":0.3851616980913312,"score_spread":0.3334648930664846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}