{"id":"W4234903414","doi":"10.1161/hyp.64.suppl_1.343","title":"Abstract 343: Endothelin-1 Overexpression Preserves Endothelial Function In Mice With Vascular Smooth Muscle Cell-specific Deletion Of Ppar-gamma","year":2014,"lang":"en","type":"article","venue":"Hypertension","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Endocrinology; Myograph; Internal medicine; Vascular smooth muscle; Peroxisome proliferator-activated receptor; Electrical impedance myography; Endothelium; Endothelin 1; Endothelin receptor; Endothelial dysfunction; Angiotensin II; Oxidative stress; Nitric oxide; Sodium nitroprusside; Vasodilation; Biology; Medicine; Chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000254425,0.0011336,0.0005402195,0.0006849216,0.0003007683,0.0004367287,0.0005446294,0.0006803874,0.00571395],"category_scores_gemma":[0.0001476543,0.0004665293,0.000594765,0.000298917,0.0006239985,0.0004357572,0.0003335207,0.001694714,0.001392932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003704146,"about_ca_system_score_gemma":0.0002794426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006131328,"about_ca_topic_score_gemma":0.000725576,"domain_scores_codex":[0.9996904,0.00003565396,0.00003538912,0.00008511174,0.00008142901,0.00007201556],"domain_scores_gemma":[0.9995642,0.00002873242,0.0001881631,0.00003757477,0.00003213248,0.0001491831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005527938,0.00009047615,0.0001386191,0.00003743041,0.00001064239,0.00007965159,0.00001605339,0.0000337314,0.9978591,0.00009494497,0.0000797317,0.001006862],"study_design_scores_gemma":[0.0003277108,0.001542658,0.01306202,0.00004438482,0.000123276,0.0009713364,0.00009425443,0.0008798732,0.9798978,0.0001967208,0.002841538,0.00001860133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876826,0.00100469,0.005735503,0.0004103121,0.0001412653,0.0000589807,0.001910654,0.0004377131,0.002618262],"genre_scores_gemma":[0.9634585,0.002104504,0.006347444,0.0004097603,0.0000964088,0.0002562556,0.003658784,0.0003260873,0.02334234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00571395,"threshold_uncertainty_score":0.01911503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01244726006715539,"score_gpt":0.2126485867224382,"score_spread":0.2002013266552829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}