{"id":"W4235161998","doi":"10.1158/1538-7445.am2019-443","title":"Abstract 443: Blood-based genotyping and clinical outcomes in patients with advanced breast cancer receiving the CDK4/6 inhibitor palbociclib in real-world settings: Results from POLARIS","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Palbociclib; Oncology; Medicine; Genotyping; Breast cancer; Internal medicine; Cancer; Circulating tumor cell; Copy-number variation; Metastatic breast cancer; Genotype; Gene; Biology; Genetics; Metastasis","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001241541,0.0003619738,0.000374794,0.0004440046,0.0003287848,0.0009725616,0.0004341804,0.0003451076,0.002205161],"category_scores_gemma":[0.001812546,0.0002355054,0.0002642316,0.0009394367,0.0004070738,0.0002955669,0.0005161185,0.0004716947,0.0007579839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001357012,"about_ca_system_score_gemma":0.00107137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02282673,"about_ca_topic_score_gemma":0.02493511,"domain_scores_codex":[0.9992847,0.0002838103,0.00004355491,0.0001609547,0.0001618118,0.00006521982],"domain_scores_gemma":[0.9980993,0.0003655832,0.0006787141,0.0001366113,0.0004275723,0.0002922992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008664539,0.0001832536,0.9801109,0.0000495207,0.0001766701,0.0001120768,0.0000887856,0.0001767257,0.0009018739,0.00003278723,0.002302248,0.007200525],"study_design_scores_gemma":[0.001665623,0.001352028,0.9925041,0.00002785616,0.0001626,0.0003508137,0.0002453015,0.0004196308,0.0006339271,0.00003559305,0.002591567,0.00001091596],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904535,0.0006211874,0.0001201442,0.0002252857,0.00001776893,0.00005641452,0.006583505,0.00001541767,0.001906867],"genre_scores_gemma":[0.9878575,0.0004334737,0.0002902236,0.0002187865,0.00004397802,0.00005395369,0.01025876,0.00001074182,0.0008327339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02282673,"threshold_uncertainty_score":0.04538774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03467973538554366,"score_gpt":0.3939951743036066,"score_spread":0.359315438918063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}