{"id":"W4235175410","doi":"10.1002/ange.201503182","title":"Biosensing by Tandem Reactions of Structure Switching, Nucleolytic Digestion, and DNA Amplification of a DNA Assembly","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Rolling circle replication; Primer (cosmetics); DNA; Aptamer; Amplicon; DNA polymerase; Multiple displacement amplification; Chemistry; DNA clamp; Molecular biology; Biophysics; Biology; Polymerase chain reaction; Biochemistry; Reverse transcriptase; DNA extraction; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004592271,0.0006268654,0.0003957225,0.0003225835,0.0001425025,0.0004256222,0.0006542388,0.0003896055,0.0004955062],"category_scores_gemma":[0.0004736516,0.0005792955,0.0002802403,0.0002586951,0.0003507916,0.0004230996,0.0004809948,0.0007007642,0.0005034946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003549777,"about_ca_system_score_gemma":0.000242038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001543756,"about_ca_topic_score_gemma":0.0002391233,"domain_scores_codex":[0.9994099,0.00007781689,0.0000462496,0.0001822928,0.0002209117,0.00006286461],"domain_scores_gemma":[0.9997382,0.0000802583,0.00007786509,0.00003229408,0.00003747326,0.00003398214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002872602,0.00001706205,0.00005736944,0.00002889731,0.000004668586,0.0000263771,0.00001370207,0.0001584456,0.9950913,0.0003152462,0.00004076141,0.004217469],"study_design_scores_gemma":[0.000003494975,0.00004668004,0.0000678166,0.000001358426,0.00000310096,0.00004871244,0.000002382229,0.001573836,0.9974663,0.00004221303,0.0007410775,0.000003088726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6784095,0.003799162,0.3091982,0.0002149304,0.0002380168,0.0002324779,0.0001356162,0.00176307,0.006009047],"genre_scores_gemma":[0.8625658,0.0008424385,0.1324788,0.00008788889,0.00003812776,0.0001474977,0.0001439981,0.000048302,0.003647279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006542388,"threshold_uncertainty_score":0.002575517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0146430521076779,"score_gpt":0.2651253312079949,"score_spread":0.250482279100317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}