{"id":"W4235442504","doi":"10.1158/1538-7445.sabcs18-ct129","title":"Abstract CT129: Identifying molecular determinants of response to apalutamide (APA) in patients (pts) with nonmetastatic castration-resistant prostate cancer (nmCRPC) in the SPARTAN study","year":2019,"lang":"en","type":"article","venue":"Clinical Trials","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Prostate cancer; Medicine; Internal medicine; Oncology; Metastasis; Transcriptome; Cancer; Androgen receptor; Biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"observational","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"design_other","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"}],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01355417,0.0002035793,0.001163921,0.0002380084,0.00003241866,0.00004234267,0.0002014487,0.0000762861,0.00006937089],"category_scores_gemma":[0.002837566,0.0001149733,0.0001427455,0.0005378107,0.0000914008,0.00009680049,0.00004754156,0.0003351158,0.00003149756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001275273,"about_ca_system_score_gemma":0.0004847139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003847614,"about_ca_topic_score_gemma":0.001155622,"domain_scores_codex":[0.9942749,0.002137646,0.001917079,0.0004929635,0.0007949891,0.0003824648],"domain_scores_gemma":[0.995859,0.002863452,0.0004470854,0.0005348081,0.0001463756,0.0001493078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04473302,0.002086301,0.9386362,0.0001376051,0.0001223765,0.0003875991,0.001557561,0.00007268199,0.005167302,0.000001079212,0.0000180557,0.007080202],"study_design_scores_gemma":[0.02083588,0.004826089,0.970128,0.0007099143,0.0001287665,9.112508e-7,0.001370501,0.00001701835,0.001798621,0.00002312606,0.00003630176,0.000124858],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924094,0.0001236911,9.70005e-7,0.0003822259,0.0001522232,0.006809733,0.00005984068,0.000006939586,0.0000549481],"genre_scores_gemma":[0.9991948,0.00004864561,0.00009003431,0.0001326321,0.00003081556,0.0003239586,0.00001091434,0.00002496284,0.0001432501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0314918,"threshold_uncertainty_score":0.4697632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2165908759653443,"score_gpt":0.5220882869166081,"score_spread":0.3054974109512638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}