{"id":"W4235803847","doi":"10.1111/epi.14557","title":"Progress report on new antiepileptic drugs: A summary of the Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV). I. Drugs in preclinical and early clinical development","year":2018,"lang":"en","type":"article","venue":"Epilepsia","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"UCB Pharma; Teva Pharmaceutical Industries; Medical Research Council; Agenzia Italiana del Farmaco, Ministero della Salute; Greenwich Biosciences; Sun Pharma; Stockholms Läns Landsting; Eisai; King's College London; Robarts Research Institute; Epilepsy Research UK; Ministero della Salute; Northwestern University; Ontario Brain Institute; GlaxoSmithKline; LivaNova; Wellcome Trust; National Institute for Health and Care Research; European Commission; U.S. Department of Defense; GW Pharmaceuticals; Sanofi; Upsher-Smith; Canadian Institutes of Health Research; Ministry of Defense; Mylan","keywords":"Antiepileptic drug; Medicine; Epilepsy; Pharmacology; Drug development; Drug discovery; partial seizures; Neuroscience; Drug; Bioinformatics; Psychiatry; Psychology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001986086,0.0006058192,0.00137185,0.0002942015,0.0002167888,0.0001072825,0.0003909544,0.0003813479,0.0001310532],"category_scores_gemma":[0.000684988,0.0003913692,0.000253073,0.0004964432,0.001213291,0.0001969488,0.0003970311,0.000985989,0.00009748527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001416152,"about_ca_system_score_gemma":0.001741954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002339021,"about_ca_topic_score_gemma":0.0001418441,"domain_scores_codex":[0.9942183,0.0004635343,0.001881305,0.001303629,0.001237186,0.0008960171],"domain_scores_gemma":[0.9959835,0.0009844401,0.0006256656,0.001157197,0.0002437457,0.001005428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002057784,0.001027846,0.9371774,0.0001827573,0.0003114922,0.0001970036,0.002500318,2.481532e-7,0.00002284587,0.0005204901,0.005874428,0.05012737],"study_design_scores_gemma":[0.006276553,0.003735231,0.9802111,0.002745736,0.0001856178,0.00007717917,0.0003001904,0.0001406424,0.000737605,0.0005237643,0.004682085,0.0003843146],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877648,0.0009146497,0.00001425557,0.004937989,0.0004577969,0.0020289,0.000008667032,0.00007150084,0.00380148],"genre_scores_gemma":[0.9921426,0.001394489,0.002232951,0.0005088549,0.000525807,0.00005523428,0.00002645656,0.00006477218,0.003048874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04974306,"threshold_uncertainty_score":0.9998538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06348653406164707,"score_gpt":0.3780976594893309,"score_spread":0.3146111254276839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}