{"id":"W4235864214","doi":"10.1172/jci200421838","title":"High-level β-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells","year":2004,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Genentech; National Institutes of Health; Stem Cell Network","keywords":"Biology; Haematopoiesis; Stem cell; Cord blood; Viral vector; Transgene; Transduction (biophysics); Genetic enhancement; Molecular biology; Progenitor cell; Transplantation; Globin; CD34; Severe combined immunodeficiency; Myeloid; Virology; Gene; Cancer research; Immunology; Cell biology; Genetics; Recombinant DNA; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003412461,0.0002088813,0.0001541773,0.0002057016,0.0001218531,0.0004654907,0.0001299884,0.0002055371,0.0008887089],"category_scores_gemma":[0.000204351,0.0001282713,0.0001204839,0.0001133184,0.0002311824,0.0001259416,0.0001751479,0.0004904591,0.0004352682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002445488,"about_ca_system_score_gemma":0.0002300685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005597563,"about_ca_topic_score_gemma":0.0005877368,"domain_scores_codex":[0.999764,0.00004473839,0.00002375431,0.00004617316,0.00008382492,0.00003753759],"domain_scores_gemma":[0.9998432,0.00002972286,0.00003980129,0.00003308263,0.00002804112,0.00002613191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002346645,0.000009741981,0.0003178703,0.000008624845,0.00000189572,0.00002579708,0.00002038377,0.00002492663,0.9980682,0.00006823572,0.0000141101,0.001416728],"study_design_scores_gemma":[0.000007373907,0.0001408201,0.00261621,0.000005236399,0.00001197446,0.0004792394,0.00001791563,0.0005974954,0.994491,0.00003514461,0.001595538,0.000002090216],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884133,0.0007001436,0.009138102,0.0000641044,0.00001314098,0.00006659157,0.0001687349,0.0001190203,0.001316793],"genre_scores_gemma":[0.993115,0.0003792605,0.003980283,0.000043049,0.000006634066,0.00002620083,0.0004123808,0.00004743625,0.001989759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008887089,"threshold_uncertainty_score":0.00297302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08391455691124541,"score_gpt":0.3641750566706373,"score_spread":0.2802604997593918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}