{"id":"W4236022293","doi":"10.22215/etd/2014-10433","title":"Less is MTOR: Regulation of Protein Synthesis via the Insulin Signaling Pathway in the Anoxia-Tolerant Red-Eared Slider Trachemys Scripta Elegans","year":2014,"lang":"en","type":"dissertation","venue":"","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"","keywords":"PI3K/AKT/mTOR pathway; Biology; mTORC1; Anoxic waters; P70-S6 Kinase 1; Protein kinase B; TSC2; Cell biology; Insulin; Effector; Hypoxia (environmental); Internal medicine; Insulin receptor; Endocrinology; Signal transduction; Chemistry; Ecology; Insulin resistance; Oxygen; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005847561,0.0003893867,0.0001595884,0.0002398135,0.0002478874,0.0002238607,0.0001670765,0.0002058384,0.001556034],"category_scores_gemma":[0.00003132519,0.0001300948,0.0002646662,0.0001271435,0.0001608175,0.0002113114,0.000175221,0.0003724472,0.0003168157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003935122,"about_ca_system_score_gemma":0.0002540379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001683993,"about_ca_topic_score_gemma":0.004140839,"domain_scores_codex":[0.999957,0.000001676696,0.000003357999,0.00001765039,0.00001079529,0.000009464227],"domain_scores_gemma":[0.9999691,0.000001498738,0.000009025161,0.000002162196,0.000005977727,0.00001219056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008546365,0.0000117141,0.0002138319,0.0000506943,0.00000383327,0.00003786034,0.000005269349,0.00003086946,0.9978242,0.00004833973,0.00006304406,0.001625041],"study_design_scores_gemma":[0.00002617304,0.0003584703,0.06967048,0.00002664216,0.00005494831,0.0003545144,0.0000565888,0.0006667688,0.9232298,0.0000847718,0.005458218,0.0000126412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898813,0.003230802,0.001339222,0.0002322507,0.00006461656,0.00002999275,0.001270296,0.0001770238,0.003774393],"genre_scores_gemma":[0.971973,0.003622752,0.002213887,0.000117591,0.00002694362,0.00005290152,0.002168994,0.00005894166,0.01976505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001683993,"threshold_uncertainty_score":0.005205452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01261715629767225,"score_gpt":0.2308748325196135,"score_spread":0.2182576762219413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}