{"id":"W4236195656","doi":"10.21203/rs.3.rs-48488/v1","title":"Metformin With Neoadjuvant Chemoradiation to Improve Pathologic Response in Rectal Cancer: a Pilot Phase I/II Trial","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University; Health Sciences Centre; Institute for Clinical Evaluative Sciences; Sunnybrook Health Science Centre; University of Toronto","funders":"","keywords":"Medicine; Colorectal cancer; Oncology; Internal medicine; Metformin; Neoadjuvant therapy; Phase (matter); Complete response; Cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009480326,0.0009088386,0.001577475,0.0002556535,0.0002834658,0.0009260522,0.0004454145,0.0009748191,0.003565942],"category_scores_gemma":[0.0009235897,0.0002846544,0.001484986,0.0003316958,0.0006569665,0.0006557301,0.0003589061,0.002346747,0.0005776635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005442353,"about_ca_system_score_gemma":0.0008263018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006001942,"about_ca_topic_score_gemma":0.00159858,"domain_scores_codex":[0.9997839,0.0001125812,0.000009690268,0.00003440905,0.00001377722,0.00004559003],"domain_scores_gemma":[0.9996321,0.0000880654,0.0000610751,0.00003481378,0.00001769075,0.0001662687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8963376,0.01313425,0.002702226,0.0007840113,0.001747356,0.0001026706,0.00007111328,0.001396697,0.007897419,0.000223685,0.002495692,0.07310726],"study_design_scores_gemma":[0.7992139,0.1818717,0.01178176,0.0001268664,0.001206509,0.0001081774,0.00007830063,0.0009760802,0.001671667,0.0004151424,0.002513433,0.00003637316],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899008,0.005279978,0.0003257347,0.001273506,0.0003972147,0.0008076964,0.0005877142,0.00005255041,0.001374822],"genre_scores_gemma":[0.9865314,0.004448993,0.001242742,0.00172884,0.0003188518,0.001426355,0.001292162,0.00003341859,0.002977083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003565942,"threshold_uncertainty_score":0.01192927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06802541873660828,"score_gpt":0.4118862959457145,"score_spread":0.3438608772091062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}