{"id":"W4236402511","doi":"10.1002/ange.201506500","title":"Controlled Transcription of Exogenous mRNA in Platelets Using Protocells","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Health Canada","keywords":"Protocell; Transcription (linguistics); RNA; Cell biology; Biology; DNA; Limiting; Messenger RNA; Eukaryotic transcription; Gene; Liposome; Computational biology; Gene expression; Genetics; Promoter; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001761712,0.0002721907,0.0001203822,0.0001416409,0.0001184222,0.0003405954,0.0001752195,0.0003094262,0.0005385526],"category_scores_gemma":[0.0001721228,0.0001245892,0.0001653706,0.000111114,0.0002282604,0.0001796251,0.0002204499,0.0005003435,0.0003460327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003944963,"about_ca_system_score_gemma":0.0002172998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006689545,"about_ca_topic_score_gemma":0.0007217182,"domain_scores_codex":[0.9998291,0.00003072858,0.00001276888,0.00003555269,0.00006736158,0.00002454875],"domain_scores_gemma":[0.9998972,0.00004173417,0.00002320948,0.00001280953,0.00001580182,0.000009088027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002430209,0.00000485589,0.0000681836,0.00002470266,0.00000269091,0.00005210964,0.00002257349,0.0001743259,0.997812,0.0007002085,0.00006098868,0.00105292],"study_design_scores_gemma":[0.000007932412,0.00003893812,0.0001064334,0.000001973131,0.000004884054,0.00002632822,0.000005439071,0.0009144231,0.9970158,0.00005222487,0.00182281,0.000002727758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.915998,0.002097925,0.0726331,0.00039978,0.0002333054,0.0001554276,0.0005400072,0.0005596246,0.007382826],"genre_scores_gemma":[0.9822499,0.0006846802,0.01274588,0.00009574219,0.00001889911,0.00007720464,0.0002044026,0.00005520862,0.003868069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006689545,"threshold_uncertainty_score":0.002862275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04660537041925001,"score_gpt":0.2756422169699989,"score_spread":0.2290368465507489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}