{"id":"W4236415918","doi":"10.21203/rs.3.rs-76129/v1","title":"Triple-Negative Breast Cancer (TNBC) Cell Metastasis is Controlled by the Opposing Actions of 5alpha-dihydroprogesterone (5alphap) and 3alpha-dihydroprogesterone (3alphahp) on Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases","year":2020,"lang":"en","type":"preprint","venue":"Research Square (Research Square)","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Canadian Breast Cancer Research Alliance","keywords":"Matrix metalloproteinase; Metastasis; Triple-negative breast cancer; Cell migration; Cancer research; Breast cancer; Estrogen receptor; Progesterone receptor; Receptor; Biology; Cell; Cancer; Chemistry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.004610361,0.0009322256,0.002033131,0.0009037064,0.0006279113,0.0001875387,0.00108471,0.0009844181,0.000108366],"category_scores_gemma":[0.001102198,0.0006731573,0.0005821781,0.001053794,0.002643498,0.00006115464,0.002687219,0.002706402,0.000004868768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001495808,"about_ca_system_score_gemma":0.0009113238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002832938,"about_ca_topic_score_gemma":0.00005960025,"domain_scores_codex":[0.9878017,0.004502587,0.001480995,0.001833754,0.003076735,0.001304207],"domain_scores_gemma":[0.9935547,0.001308575,0.0009687139,0.00147057,0.002030002,0.0006674755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007071615,0.001117114,0.0001980716,0.00404054,0.001338574,0.00004412724,0.0008083255,0.00008862992,0.9776619,0.00005036191,0.001907005,0.005673742],"study_design_scores_gemma":[0.005130897,0.005048352,0.0001904186,0.002000418,0.000359369,0.00003300346,0.001459297,0.0002544223,0.9840621,0.0002830236,0.0006502577,0.0005284893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9328787,0.05386973,0.00008005385,0.002075492,0.000113535,0.008200361,0.002611104,0.00002984619,0.0001411534],"genre_scores_gemma":[0.9817329,0.01493169,0.0004848196,0.00002115484,0.0002028389,0.001661753,0.0002540969,0.0001662044,0.000544558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04885416,"threshold_uncertainty_score":0.9995944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04981688225079618,"score_gpt":0.3909784531408507,"score_spread":0.3411615708900545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}