{"id":"W4236415918","doi":"10.21203/rs.3.rs-76129/v1","title":"Triple-Negative Breast Cancer (TNBC) Cell Metastasis is Controlled by the Opposing Actions of 5alpha-dihydroprogesterone (5alphap) and 3alpha-dihydroprogesterone (3alphahp) on Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases","year":2020,"lang":"en","type":"preprint","venue":"Research Square (Research Square)","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Canadian Breast Cancer Research Alliance","keywords":"Matrix metalloproteinase; Metastasis; Triple-negative breast cancer; Cell migration; Cancer research; Breast cancer; Estrogen receptor; Progesterone receptor; Receptor; Biology; Cell; Cancer; Chemistry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009694727,0.0002693664,0.0002188814,0.0001587782,0.0001707943,0.000308845,0.00009706568,0.0001338819,0.001748729],"category_scores_gemma":[0.00009084544,0.00008694671,0.0002044096,0.0001453731,0.0001677479,0.0001548534,0.0001340468,0.0002250433,0.0003310753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002374704,"about_ca_system_score_gemma":0.000252665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001695263,"about_ca_topic_score_gemma":0.002828308,"domain_scores_codex":[0.9998862,0.00001398216,0.000008112313,0.00001744764,0.00004504536,0.00002925639],"domain_scores_gemma":[0.9999481,0.000008087232,0.00001556148,0.000002687339,0.000009574471,0.00001587973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001604277,0.00002339315,0.0006440026,0.0001044039,0.000004415888,0.0001276109,0.00002298453,0.00001839553,0.9964185,0.00005985638,0.0001229792,0.002292992],"study_design_scores_gemma":[0.00003111416,0.001090812,0.04895747,0.0000275175,0.0000359141,0.001214235,0.0001736889,0.000400784,0.9367688,0.00006975555,0.0112181,0.00001165399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815247,0.01360196,0.001168973,0.0001841572,0.00006894425,0.00005646202,0.0007733756,0.00005765574,0.002563872],"genre_scores_gemma":[0.9847941,0.008475224,0.001238362,0.0001176912,0.00002659744,0.00006206719,0.0007155198,0.000007417634,0.004563037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001748729,"threshold_uncertainty_score":0.005850136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04981688225079618,"score_gpt":0.3909784531408507,"score_spread":0.3411615708900545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}