{"id":"W4236592345","doi":"10.3410/f.7127958.7358060","title":"Faculty Opinions recommendation of ERK1/2 MAP kinases promote cell cycle entry by rapid, kinase-independent disruption of retinoblastoma-lamin A complexes.","year":2010,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Kinase; Retinoblastoma; Lamin; Mitogen-activated protein kinase; Cell biology; Chemistry; Cancer research; Biochemistry; Biology; Nucleus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008720551,0.002016927,0.001209866,0.002400877,0.0005507211,0.001932362,0.001802252,0.001544641,0.02956724],"category_scores_gemma":[0.004809321,0.0004353946,0.001472178,0.003565367,0.0002690581,0.0007894397,0.001076248,0.001187238,0.02662647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001376731,"about_ca_system_score_gemma":0.002337479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02545621,"about_ca_topic_score_gemma":0.0651965,"domain_scores_codex":[0.9991164,0.0001412284,0.00009238586,0.000293026,0.0002339634,0.0001230061],"domain_scores_gemma":[0.9983159,0.0005443601,0.0002798041,0.0002907758,0.0003362613,0.0002328836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005796428,0.00008079699,0.006603585,0.002035221,0.0002729855,0.00006820785,0.00002461177,0.0009016888,0.0006865966,0.0003652658,0.9801533,0.008227963],"study_design_scores_gemma":[0.001413848,0.000104075,0.04527065,0.0005620489,0.0004640246,0.0002107583,0.00009727578,0.002343209,0.002896284,0.001197783,0.9453756,0.00006450086],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.001211049,0.0003392715,0.00005442537,0.0001270337,0.00002820206,0.00001001372,0.9970752,0.0002566858,0.0008980524],"genre_scores_gemma":[0.002188468,0.00017359,0.0002413382,0.00005491716,0.000009847335,0.000033845,0.9963476,0.00003287087,0.0009175194],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.02956724,"threshold_uncertainty_score":0.0989123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01363011854455197,"score_gpt":0.3000525936400417,"score_spread":0.2864224750954897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}