{"id":"W4236749136","doi":"10.21203/rs.3.rs-237354/v1","title":"Gastrointestinal and Genitourinary Toxicity Profiles of Metformin Versus Placebo in Men With Prostate Cancer Receiving Pelvic Radiotherapy: Interim Toxicity Results of a Double-blinded, Multicenter, Phase II Randomized Controlled Trial","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"CancerCare Manitoba; University of Manitoba; University of Calgary; University of Alberta","funders":"","keywords":"Medicine; Genitourinary system; Interim analysis; Toxicity; Prostate cancer; Radiation therapy; Double blinded; Urology; Prostate; Placebo; Interim; Internal medicine; Oncology; Multicenter study; Randomized controlled trial; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00304262,0.001794971,0.003638634,0.0004938869,0.0004917874,0.00122838,0.000911977,0.001923383,0.005995082],"category_scores_gemma":[0.00469672,0.0008065988,0.002782871,0.0005027106,0.001172074,0.001131045,0.0004663639,0.002678422,0.0006056114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007639501,"about_ca_system_score_gemma":0.001281092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007260788,"about_ca_topic_score_gemma":0.001296659,"domain_scores_codex":[0.9984143,0.001126272,0.00008860663,0.0001720929,0.00008793327,0.0001108925],"domain_scores_gemma":[0.9978829,0.0008621484,0.0006389645,0.0001629044,0.0001213318,0.0003317333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9868174,0.003029846,0.0003091084,0.0002954747,0.0006901234,0.00001111002,0.00002203546,0.000158247,0.0007924488,0.00002485439,0.0002140333,0.007635408],"study_design_scores_gemma":[0.9319115,0.06517583,0.001395387,0.00003079493,0.0006482936,0.00001470336,0.0000148395,0.0002378133,0.0002959471,0.00007485026,0.0001859731,0.00001407455],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900261,0.004630111,0.0006476179,0.0004741233,0.0003592806,0.00204006,0.000730852,0.00008494817,0.001007001],"genre_scores_gemma":[0.9881679,0.002610177,0.002133157,0.000727742,0.0004922862,0.002481919,0.0007523052,0.00003803409,0.002596349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005995082,"threshold_uncertainty_score":0.02005559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08111941724918288,"score_gpt":0.4298948189562416,"score_spread":0.3487754017070587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}