{"id":"W4236867910","doi":"10.22541/au.161744225.57876883/v1","title":"Biological treatment provides disease-modifying immunological effects","year":2021,"lang":"en","type":"preprint","venue":"","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Omalizumab; Mepolizumab; Benralizumab; Medicine; Immunology; Dupilumab; Asthma; Atopic dermatitis; Disease; Endotype; Immunoglobulin E; Allergy; Eosinophil; Antibody; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000339996,0.0004070544,0.000464211,0.0003679346,0.0002145896,0.0006521185,0.0002253431,0.0005344371,0.01358266],"category_scores_gemma":[0.0003583478,0.0001139816,0.0004569993,0.0001991404,0.0003032523,0.0004016807,0.0003949514,0.000915924,0.004603675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002148349,"about_ca_system_score_gemma":0.0002246375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001196484,"about_ca_topic_score_gemma":0.0001669674,"domain_scores_codex":[0.9997494,0.00005799473,0.00001572447,0.00003964035,0.00009766459,0.00003964701],"domain_scores_gemma":[0.9998624,0.00002979495,0.00002670999,0.00002831074,0.00002749582,0.0000251836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007306943,0.0007291786,0.001373118,0.00249555,0.0001666543,0.0005906786,0.0001217231,0.0005372582,0.6607246,0.01215177,0.01780549,0.3025734],"study_design_scores_gemma":[0.0002906093,0.00219958,0.006904201,0.0002576047,0.0002420978,0.003323208,0.0001114064,0.0009095928,0.3094526,0.00631186,0.6699659,0.00003131224],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.333094,0.3642247,0.07220118,0.01262474,0.00760352,0.000779934,0.002713616,0.002239232,0.204519],"genre_scores_gemma":[0.8351736,0.07257102,0.01933445,0.004145507,0.002005093,0.0004631701,0.001796432,0.0002622033,0.06424851],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01358266,"threshold_uncertainty_score":0.04543847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04901834906175955,"score_gpt":0.3189728767480464,"score_spread":0.2699545276862869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}