{"id":"W4236932772","doi":"10.21203/rs.2.142/v1","title":"RTS,S malaria vaccine pilot studies: addressing the human realities in large-scale clinical trials","year":2018,"lang":"en","type":"preprint","venue":"Research Square","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"International Development Research Centre; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Malaria; Malaria vaccine; Clinical trial; Public health; Intervention (counseling); Medicine; Scale (ratio); Community engagement; Environmental health; Political science; Nursing; Public relations; Geography; Immunology; Plasmodium falciparum","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.5061137,0.001295676,0.001773436,0.0009153277,0.002376034,0.006310112,0.00239731,0.003706705,0.006349882],"category_scores_gemma":[0.4688728,0.0009337902,0.001161118,0.001614117,0.006507801,0.005013951,0.003988622,0.004658885,0.001327337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003404879,"about_ca_system_score_gemma":0.0200827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008590921,"about_ca_topic_score_gemma":0.002411309,"domain_scores_codex":[0.4780705,0.4947303,0.01191442,0.002187539,0.01062286,0.002474332],"domain_scores_gemma":[0.4464289,0.4238181,0.04137338,0.04541868,0.03350372,0.009457164],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"design_other","study_design_gemma":"qualitative","study_design_scores_codex":[0.08658322,0.02411713,0.04819447,0.02790461,0.00634731,0.002615712,0.02849707,0.01045353,0.0121566,0.09545395,0.04671318,0.6109633],"study_design_scores_gemma":[0.0803811,0.3131966,0.06093257,0.02365061,0.005326748,0.001852183,0.01704773,0.01264343,0.01825398,0.1607646,0.3053429,0.000607443],"study_design_candidate":"qualitative","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4076675,0.02011062,0.1248684,0.1734809,0.007726782,0.2182681,0.001776362,0.0006986153,0.04540281],"genre_scores_gemma":[0.6738992,0.005746603,0.1512996,0.01478912,0.002208032,0.1474247,0.0005312109,0.0001596543,0.003942024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4938863,"threshold_uncertainty_score":0.6090498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.660316715545663,"score_gpt":0.6371397305023873,"score_spread":0.0231769850432757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}