{"id":"W4237117456","doi":"10.26434/chemrxiv.12510011.v2","title":"Human Neuraminidases Have Reduced Activity Towards Modified Sialic Acids on Glycoproteins","year":2020,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Glycomics Centre; Universities Space Research Association","keywords":"Glycoprotein; Substrate (aquarium); Enzyme; Sialic acid; Biochemistry; Mucin; Glycolipid; Chemistry; Neuraminidase; Acetylation; Substrate specificity; Biology; Ecology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001865097,0.0002802633,0.0001852973,0.0001126186,0.00006344869,0.0001930388,0.000116728,0.000171981,0.001491228],"category_scores_gemma":[0.0002275071,0.00008348736,0.0001598493,0.0001448084,0.0001560651,0.0001214989,0.000140532,0.000196026,0.0003563105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001362999,"about_ca_system_score_gemma":0.00009073376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001025513,"about_ca_topic_score_gemma":0.0009139978,"domain_scores_codex":[0.9998744,0.00002787136,0.00001005863,0.00002233505,0.0000392867,0.00002605926],"domain_scores_gemma":[0.9999187,0.00002085706,0.00001650762,0.00001608064,0.0000147139,0.00001324391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001473979,0.000006950546,0.0007572084,0.00002514801,0.00001001569,0.00006614941,0.00003207748,0.00004932289,0.9964678,0.00006924344,0.0000257472,0.00234295],"study_design_scores_gemma":[0.000004071158,0.0001518053,0.009630703,0.000002373361,0.00001071179,0.0005052583,0.00003471482,0.0001909785,0.9879491,0.00003664462,0.001480327,0.000003241646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966696,0.0008223135,0.001496649,0.00002445907,0.000005694369,0.000005752192,0.0001743372,0.00002664443,0.0007745871],"genre_scores_gemma":[0.9947519,0.0005818089,0.00123223,0.00002300647,0.000003678772,0.000006820862,0.0006828745,0.0000147369,0.002703011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001491228,"threshold_uncertainty_score":0.004988611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06984655140626159,"score_gpt":0.3427618676910832,"score_spread":0.2729153162848217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}