{"id":"W4237165348","doi":"10.1101/2021.03.15.21251990","title":"Real-world effects of ACE inhibitors and Angiotensin Receptor Blockers: protocol for an emulation study of the ONTARGET trial using electronic health records","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Blood Pressure and Hypertension Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Impact","funders":"Medical Research Council; GlaxoSmithKline","keywords":"Medicine; Clinical trial; Internal medicine; Propensity score matching; Population; Heart failure; Cohort; Ramipril; Stroke (engine); Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.09150285,0.004412317,0.005867007,0.00266953,0.002765233,0.004901583,0.002705076,0.006780442,0.05828235],"category_scores_gemma":[0.1155611,0.002648739,0.006424178,0.004035522,0.00358105,0.003859169,0.003091498,0.006253249,0.01626903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005440276,"about_ca_system_score_gemma":0.01225544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001814892,"about_ca_topic_score_gemma":0.002506791,"domain_scores_codex":[0.9449853,0.03744521,0.008330418,0.002909839,0.003669413,0.002659874],"domain_scores_gemma":[0.939573,0.02177705,0.01152805,0.0119476,0.01260218,0.002571923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.6874452,0.0237998,0.005796497,0.04502746,0.007901431,0.001088084,0.002656949,0.008831924,0.00454647,0.02342627,0.09745903,0.09202094],"study_design_scores_gemma":[0.6631009,0.04527504,0.01868744,0.01664339,0.003371998,0.0003591702,0.0007815618,0.006661486,0.003432478,0.01527612,0.2258579,0.0005525555],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.001551789,0.0001136543,0.002028981,0.0001987359,0.0002171914,0.9927538,0.002045183,0.00006454792,0.001026158],"genre_scores_gemma":[0.001050318,0.00004067115,0.001175791,0.00009089828,0.00002766554,0.9971854,0.000267011,0.000004542288,0.0001576601],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.09150285,"threshold_uncertainty_score":0.4839191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06497930353825941,"score_gpt":0.3718569123364128,"score_spread":0.3068776087981534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}