{"id":"W4237220482","doi":"10.3410/f.736688148.793580848","title":"Faculty Opinions recommendation of Distinct Alterations in Tricarboxylic Acid Cycle Metabolites Associate with Cancer and Autism Phenotypes in Cowden Syndrome and Bannayan-Riley-Ruvalcaba Syndrome.","year":2020,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Cowden syndrome; Phenotype; PTEN; Autism; Tricarboxylic acid; Bioinformatics; Cancer research; Genetics; Biology; Psychology; Citric acid cycle; Medicine; Biochemistry; Psychiatry; Gene; Metabolism; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001233873,0.001196638,0.001300525,0.002140763,0.0006461128,0.001839853,0.001973115,0.001725946,0.05229717],"category_scores_gemma":[0.01120656,0.0004297997,0.001434258,0.003498082,0.0002234364,0.0009224921,0.001672638,0.001288545,0.03223896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001040035,"about_ca_system_score_gemma":0.002380824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01835305,"about_ca_topic_score_gemma":0.05337822,"domain_scores_codex":[0.9989482,0.0001955431,0.0001333029,0.0003028255,0.0002937074,0.0001265907],"domain_scores_gemma":[0.9961147,0.001389679,0.0005980234,0.0004844909,0.0009182962,0.0004948062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002078162,0.0000213095,0.005830387,0.001655253,0.0001913954,0.00006010394,0.000019418,0.0001902587,0.00024065,0.0002918484,0.9860954,0.005196223],"study_design_scores_gemma":[0.0007382601,0.00004015263,0.03959093,0.001080107,0.0004225259,0.0003047588,0.00008251831,0.0005013882,0.0007008382,0.001193179,0.9552923,0.00005304087],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.0004133573,0.0003407655,0.00004819376,0.0002242408,0.0000421017,0.00001157227,0.9978042,0.0001381688,0.0009773585],"genre_scores_gemma":[0.001712448,0.0002712623,0.0002641917,0.0002105485,0.00002196398,0.00007079061,0.9959599,0.0000487408,0.001440076],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.05229717,"threshold_uncertainty_score":0.1749515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01784210802156359,"score_gpt":0.3192209675234948,"score_spread":0.3013788595019312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}