{"id":"W4237269508","doi":"10.1002/anie.201809928","title":"Facile Formation of β‐thioGlcNAc Linkages to Thiol‐Containing Sugars, Peptides, and Proteins using a Mutant GH20 Hexosaminidase","year":2018,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Glycomics Network; Canadian Institutes of Health Research; Austrian Science Fund","keywords":"Chemistry; Biochemistry; Thiol; Cysteine; Enzyme; Alanine; Amino acid; Mutant; Thio-; Glycoside hydrolase; Hydrolase; Stereochemistry; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001762818,0.0001909465,0.0002050864,0.00009259212,0.0001130584,0.00006422976,0.0001752268,0.0001543449,0.000879543],"category_scores_gemma":[0.0003551479,0.0001981894,0.000080032,0.0001104819,0.0001065979,0.0003894978,0.0001210524,0.0001379291,0.00001058843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001653605,"about_ca_system_score_gemma":0.00004479427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001044298,"about_ca_topic_score_gemma":0.00002490699,"domain_scores_codex":[0.9987444,0.00000945974,0.000398996,0.0002973351,0.0003508341,0.0001989612],"domain_scores_gemma":[0.9990226,0.00009487032,0.000232583,0.0001908624,0.0003484577,0.0001106389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008484473,0.00005053481,0.0003395337,0.0001182632,0.0000431677,0.000007140901,0.0009695609,0.000004637221,0.9969922,0.00004490852,0.0003256852,0.001019496],"study_design_scores_gemma":[0.0003821648,0.00004514479,0.000102542,0.0003461477,0.00003239439,0.00004722461,0.0007792901,0.0009199314,0.9946988,0.0002613107,0.002174246,0.0002108476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98478,0.00002714911,0.002134272,0.0002902012,0.0002030312,0.0001078869,0.0003300319,0.00006112145,0.01206629],"genre_scores_gemma":[0.9963573,0.00002695883,0.001431011,0.00009818508,0.001403313,0.00004150907,0.0004118399,0.00001936939,0.0002105692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01185572,"threshold_uncertainty_score":0.963038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02557740888602442,"score_gpt":0.2664584054484426,"score_spread":0.2408809965624182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}