{"id":"W4237315872","doi":"10.1021/acscatal.8b00666","title":"Structural Dynamics and Catalytic Properties of a Multimodular Xanthanase","year":2018,"lang":"en","type":"article","venue":"ACS Catalysis","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; British Columbia Knowledge Development Fund; Danmarks Frie Forskningsfond; Canada Foundation for Innovation","keywords":"Chemistry; Hydrogen–deuterium exchange; Glycoside hydrolase; Protein engineering; Enzyme; Hydrolase; Mass spectrometry; Protein structure; Biochemistry; Stereochemistry; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009503362,0.0001157239,0.00009673369,0.0001124712,0.0001304502,0.0002478716,0.0001885798,0.0001452101,0.0005203305],"category_scores_gemma":[0.0001898292,0.00009289889,0.0001191108,0.000104335,0.0001440921,0.0002200669,0.0001146646,0.0002643853,0.0001208087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002113019,"about_ca_system_score_gemma":0.00008671983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000877159,"about_ca_topic_score_gemma":0.0004188064,"domain_scores_codex":[0.9999648,0.000003653653,0.000001904912,0.00001094819,0.00001167054,0.000006958117],"domain_scores_gemma":[0.9999139,0.00002039049,0.00002050488,0.000008545088,0.00001591731,0.00002062947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001168315,0.00003701564,0.004179412,0.00002062786,0.00001392239,0.00007904445,0.00008377677,0.0007588386,0.9929054,0.0001660501,0.00003368436,0.001605432],"study_design_scores_gemma":[0.00001968776,0.0003586389,0.05846225,0.000006843949,0.00002134365,0.000554286,0.0001755996,0.03862961,0.8996131,0.0003613924,0.001767629,0.00002956024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994482,0.00007930639,0.000303228,0.00001211523,0.000001093013,9.231445e-7,0.00003018977,0.000003534512,0.0001214357],"genre_scores_gemma":[0.9989045,0.00008647351,0.0005231539,0.000006340995,0.00000135139,0.000002709845,0.0001909957,0.000004413753,0.0002802226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000877159,"threshold_uncertainty_score":0.001744092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009687727362750082,"score_gpt":0.220236107476052,"score_spread":0.2105483801133019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}