{"id":"W4237315872","doi":"10.1021/acscatal.8b00666","title":"Structural Dynamics and Catalytic Properties of a Multimodular Xanthanase","year":2018,"lang":"en","type":"article","venue":"ACS Catalysis","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; British Columbia Knowledge Development Fund; Danmarks Frie Forskningsfond; Canada Foundation for Innovation","keywords":"Chemistry; Hydrogen–deuterium exchange; Glycoside hydrolase; Protein engineering; Enzyme; Hydrolase; Mass spectrometry; Protein structure; Biochemistry; Stereochemistry; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004517517,0.00007309041,0.00008651997,0.00003580462,0.00005060509,0.000009699998,0.00006556395,0.00005062134,0.000005511897],"category_scores_gemma":[0.00005338904,0.00006271734,0.00002642512,0.00008250709,0.0001538239,0.000008008572,0.00006150679,0.00002237713,0.00000291922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006025418,"about_ca_system_score_gemma":0.00001454947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006145152,"about_ca_topic_score_gemma":0.00008620849,"domain_scores_codex":[0.9995431,0.00001285536,0.0001151748,0.0001896709,0.00005930154,0.00007986704],"domain_scores_gemma":[0.9995669,8.465198e-7,0.00005978177,0.0002337482,0.0001092945,0.00002947888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000259782,0.00001068371,0.002301099,0.00002183308,0.00004864819,1.960977e-7,0.0001142483,0.000002406007,0.9934458,0.00002669948,0.00002280917,0.003979655],"study_design_scores_gemma":[0.0001361376,0.0000595341,0.003989279,0.000005730989,0.00003824467,0.000008810027,0.00009430767,0.001405445,0.994022,0.000004912226,0.0001518074,0.00008378313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992731,0.000226553,0.000208421,0.000127338,0.00005521897,0.0000572496,0.00001468452,0.000006361933,0.00003104134],"genre_scores_gemma":[0.9989265,0.0000431295,0.00009731395,0.00005660094,0.0001151141,0.000003775658,0.0003949133,0.00000900724,0.0003536921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003895872,"threshold_uncertainty_score":0.2557539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009687727362750082,"score_gpt":0.220236107476052,"score_spread":0.2105483801133019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}