{"id":"W4237364272","doi":"10.1136/annrheumdis-2021-eular.409","title":"POS1027 EFFICACY AND SAFETY OF GUSELKUMAB, A MONOCLONAL ANTIBODY SPECIFIC TO THE p19-SUBUNIT OF INTERLEUKIN-23, THROUGH 2 YEARS: RESULTS FROM A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY CONDUCTED IN BIOLOGIC-NAÏVE PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS","year":2021,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Medicine; Population; Placebo; Discontinuation; Adverse effect; Internal medicine; Tolerability; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001345512,0.001037145,0.002562085,0.0004640905,0.0004706061,0.000891706,0.0006540823,0.001765443,0.003573094],"category_scores_gemma":[0.001115455,0.000550402,0.001639275,0.0004087965,0.001181702,0.001409193,0.0002747406,0.003121642,0.001065906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004097342,"about_ca_system_score_gemma":0.0007265727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004638968,"about_ca_topic_score_gemma":0.0009785324,"domain_scores_codex":[0.9993981,0.0002746619,0.00004337671,0.00009255869,0.00006400893,0.0001272965],"domain_scores_gemma":[0.9992673,0.0002099639,0.0001503341,0.00005278709,0.00004518393,0.0002744411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9111131,0.01581543,0.002306422,0.0005963654,0.0009455665,0.0001542675,0.0000854383,0.0007002016,0.01734199,0.0001229387,0.000877995,0.04994019],"study_design_scores_gemma":[0.5762486,0.4039202,0.01440208,0.00005038155,0.000815887,0.0001820217,0.00005793895,0.0007286729,0.002553208,0.0001648287,0.0008370529,0.00003901451],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929922,0.004017779,0.0002820794,0.0002783693,0.0001773755,0.000349567,0.0005036732,0.0001070343,0.001292082],"genre_scores_gemma":[0.9951497,0.001573117,0.0003422341,0.0005681653,0.0001729369,0.0003395198,0.0007439002,0.00002169968,0.001088719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003573094,"threshold_uncertainty_score":0.01195318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04501951089408203,"score_gpt":0.3434633701486586,"score_spread":0.2984438592545766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}