{"id":"W4237365222","doi":"10.1093/neuonc/nox168.1130","title":"SCDT-51. INITIAL EXPERIENCE OF BLOOD-BRAIN BARRIER OPENING FOR CHEMOTHERAPEUTIC-DRUG DELIVERY TO BRAIN TUMOURS BY MR-GUIDED FOCUSED ULTRASOUND","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Scottish Cot Death Trust","keywords":"Medicine; Microbubbles; Blood–brain barrier; Extravasation; Magnetic resonance imaging; Glioma; Focused ultrasound; Drug delivery; Ultrasound; Radiology; Pathology; Internal medicine; Central nervous system; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00024285,0.0002418997,0.0004317663,0.00007570293,0.0003823206,0.0001187216,0.0007683876,0.0001641473,0.0001486203],"category_scores_gemma":[0.0005690302,0.0002765483,0.0001183567,0.00009518061,0.0002062355,0.0002161864,0.00006774138,0.000215632,0.0000205893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006153201,"about_ca_system_score_gemma":0.0001140862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001703409,"about_ca_topic_score_gemma":0.0002692111,"domain_scores_codex":[0.998465,0.00005776848,0.0004198095,0.0004034699,0.0001517579,0.000502191],"domain_scores_gemma":[0.9974847,0.001409293,0.0001441044,0.0006523262,0.00009371655,0.0002158051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003506201,0.00006980335,0.0007025545,0.00002221008,0.0000443126,0.000004089766,0.002457319,0.0001117355,0.9734936,0.00009759358,0.01765664,0.005305038],"study_design_scores_gemma":[0.002193359,0.0002952605,0.0005441197,0.00002165699,0.00007740334,0.00006522649,0.0003945534,0.0005585321,0.7097881,0.0002078809,0.2854483,0.0004055852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914608,0.00008892723,0.002071217,0.002276461,0.0003815045,0.0007910849,0.0001404327,0.0001477722,0.002641806],"genre_scores_gemma":[0.9929826,0.00002739918,0.002921796,0.003130901,0.0002217428,0.000429671,0.00001973601,0.00008938583,0.0001768076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2677917,"threshold_uncertainty_score":0.9999686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02713639470532464,"score_gpt":0.3085902262507642,"score_spread":0.2814538315454396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}