{"id":"W4237370638","doi":"10.1007/978-1-4614-5626-1_27","title":"Prion Biomarkers","year":2012,"lang":"en","type":"book-chapter","venue":"","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"","keywords":"Bovine spongiform encephalopathy; Transmissible spongiform encephalopathy; Prion protein; Disease; Biology; Biomarker; Virology; Computational biology; Medicine; Pathology; Scrapie; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007849905,0.001316965,0.0007738767,0.002367263,0.0006027027,0.001997841,0.001028672,0.00154988,0.02635821],"category_scores_gemma":[0.0008844614,0.0004289628,0.0004153538,0.001309518,0.000635933,0.001700059,0.001112328,0.00175389,0.02763101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006004179,"about_ca_system_score_gemma":0.0005308697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004293087,"about_ca_topic_score_gemma":0.0008725313,"domain_scores_codex":[0.9994885,0.00007171983,0.00002872066,0.0001105148,0.0002576334,0.00004294345],"domain_scores_gemma":[0.9997128,0.00004917818,0.00003208519,0.00004413781,0.0001243081,0.00003753913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003112705,0.0001808683,0.0004549183,0.001477682,0.0000523081,0.0007710973,0.0001631371,0.0003214341,0.1722912,0.04136189,0.1761194,0.6064948],"study_design_scores_gemma":[0.00001935815,0.0001334761,0.0006615879,0.0003070107,0.00003582382,0.002136375,0.00005147141,0.0003754118,0.06077038,0.0160902,0.9193851,0.00003373759],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"review","genre_scores_codex":[0.01544719,0.3175536,0.1039462,0.008958111,0.01166076,0.0006991913,0.004017054,0.003117812,0.5346002],"genre_scores_gemma":[0.05904726,0.120858,0.05213749,0.004974111,0.0029589,0.0005777548,0.005849907,0.000531968,0.7530646],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.02635821,"threshold_uncertainty_score":0.08817703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01273447803251012,"score_gpt":0.2332612377363107,"score_spread":0.2205267597038006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}