{"id":"W4237457482","doi":"10.21203/rs.3.rs-59510/v1","title":"Efficacy and Safety of CD22 Chimeric Antigen Receptor (CAR) T-cell Therapy in Patients With B-cell Malignancies: A Protocol for a Systematic Review and Meta-analysis","year":2020,"lang":"en","type":"review","venue":"Research Square","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Western University; Ottawa Hospital; University of British Columbia","funders":"","keywords":"Chimeric antigen receptor; Meta-analysis; CD22; Medicine; Protocol (science); B cell; Immunotherapy; Oncology; Immunology; Internal medicine; Cancer; Antibody; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03364016,0.004095162,0.02707737,0.01342724,0.001737196,0.005043279,0.004283001,0.004043036,0.02158574],"category_scores_gemma":[0.05417635,0.002659403,0.03769725,0.01158585,0.001924564,0.004412511,0.004210153,0.002598683,0.001825853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008854366,"about_ca_system_score_gemma":0.02230005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005809846,"about_ca_topic_score_gemma":0.01163865,"domain_scores_codex":[0.9765223,0.008782897,0.009262467,0.002069583,0.002600739,0.0007620463],"domain_scores_gemma":[0.9799349,0.008938708,0.00569666,0.001434733,0.003474714,0.0005202347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.001330367,0.0000350654,0.0005883979,0.9543045,0.03225198,0.0001072918,0.000181279,0.0004086689,0.0003393412,0.0005027843,0.002511657,0.007438817],"study_design_scores_gemma":[0.01002841,0.0009428192,0.005014202,0.5260462,0.4128809,0.0002676856,0.0004483741,0.0009148432,0.0008291932,0.003018071,0.0393519,0.000257392],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.008634687,0.2958743,0.01374441,0.003107736,0.001430596,0.6383685,0.0353799,0.0006642109,0.002795562],"genre_scores_gemma":[0.01944483,0.07952755,0.01479877,0.00228982,0.0001958564,0.8769186,0.005197711,0.00008913184,0.001537836],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.03364016,"threshold_uncertainty_score":0.1779083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1348959426903898,"score_gpt":0.4454888473819936,"score_spread":0.3105929046916038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}