{"id":"W4237668787","doi":"10.3410/f.735618973.793580843","title":"Faculty Opinions recommendation of Numb inhibits epithelial-mesenchymal transition via RBP-Jκ-dependent Notch1/PTEN/FAK signaling pathway in tongue cancer.","year":2020,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"NUMB; PTEN; Gene knockdown; Cancer research; Epithelial–mesenchymal transition; Cancer; Western blot; Cell growth; Chemistry; Cell migration; Carcinogenesis; Cell; Gentamicin protection assay; Biology; Metastasis; Signal transduction; Cell biology; PI3K/AKT/mTOR pathway; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001131056,0.000429409,0.0005392501,0.001148002,0.001227598,0.001832816,0.0008485363,0.001492018,0.2748568],"category_scores_gemma":[0.002055467,0.0002847484,0.000615924,0.001269135,0.0003135223,0.0008174154,0.0008800484,0.001376493,0.08295177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001233877,"about_ca_system_score_gemma":0.003211358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003421595,"about_ca_topic_score_gemma":0.01017751,"domain_scores_codex":[0.9991663,0.000056838,0.00005182972,0.00008790541,0.0005282132,0.000108995],"domain_scores_gemma":[0.9981269,0.00008369827,0.0001769747,0.00007588034,0.0009948087,0.0005417204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000342972,0.0002060109,0.001747121,0.001409027,0.00004964522,0.0003505715,0.0001380841,0.000136712,0.05476441,0.001215367,0.7269778,0.2126623],"study_design_scores_gemma":[0.00007564975,0.0001220063,0.00436197,0.0002409607,0.00004846771,0.0002272955,0.0001988613,0.0002477937,0.01126066,0.0005500574,0.9826435,0.00002277489],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"dataset","genre_scores_codex":[0.04423995,0.05552448,0.01093069,0.1438324,0.0627845,0.001435345,0.02511176,0.004627462,0.6515134],"genre_scores_gemma":[0.0786033,0.05098148,0.008717455,0.01948181,0.01526229,0.0004452646,0.01125172,0.000816779,0.81444],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.2748568,"threshold_uncertainty_score":0.9194876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02317885115189556,"score_gpt":0.3386966065575286,"score_spread":0.315517755405633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}