{"id":"W4237725997","doi":"10.26434/chemrxiv.7212836","title":"An Activity-based Probe Targeting Non-catalytic, Highly Conserved Amino Acid Residues Within Bromodomains","year":2018,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novartis Pharma; Ministero dello Sviluppo Economico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Medical Research Council; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Ministry of Economic Development and Innovation; Genome Canada; Pfizer","keywords":"Bromodomain; Druggability; Biochemistry; Small molecule; Bioorthogonal chemistry; Lysine; Amino acid; Recombinant DNA; Transcription factor; Chemistry; Biology; Endogeny; Epigenetics; Cell biology; Gene; Click chemistry; Combinatorial chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003812277,0.0004192415,0.0002900596,0.0001924032,0.00017475,0.0003441125,0.000495319,0.000794529,0.001410933],"category_scores_gemma":[0.0002638899,0.0001959606,0.0002366355,0.0001349377,0.000439297,0.0002812462,0.0002825161,0.001018495,0.0005012156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004909954,"about_ca_system_score_gemma":0.0002785999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004473109,"about_ca_topic_score_gemma":0.0004146682,"domain_scores_codex":[0.9997938,0.0000386804,0.000007730489,0.00007573241,0.00004084214,0.00004315769],"domain_scores_gemma":[0.9998168,0.00006662977,0.00004765164,0.00002244144,0.00001477782,0.00003164406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003328191,0.00000691687,0.00002831247,0.00003356659,0.00000223987,0.00002486304,0.00001094509,0.0000298848,0.9988952,0.0001816728,0.000037185,0.0007159194],"study_design_scores_gemma":[0.000007070842,0.00005892625,0.0001805636,0.000001536442,0.000003349097,0.00008467626,0.000004638335,0.0001828446,0.9980302,0.00002124556,0.00142301,0.000001993116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8881664,0.00365825,0.09801818,0.0007692557,0.0001308174,0.0001663677,0.0005925766,0.0005378317,0.007960309],"genre_scores_gemma":[0.954838,0.001177091,0.03561222,0.0002812115,0.00002879482,0.0001008746,0.0004063025,0.00007009928,0.00748544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001410933,"threshold_uncertainty_score":0.004720032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01658239049640154,"score_gpt":0.2603922376318082,"score_spread":0.2438098471354067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}