{"id":"W4237732428","doi":"10.1172/jci0213359","title":"Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility","year":2002,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Universidad Nacional de La Plata; Heart and Stroke Foundation of Canada; Johns Hopkins University; American Heart Association","keywords":"Contractility; Repolarization; Heart failure; Medicine; Calcium; Heartbeat; Internal medicine; Cardiology; Endocrinology; Biology; Electrophysiology; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001583358,0.0001171183,0.0002623507,0.00004523543,0.00007281401,0.00005729185,0.00009143832,0.0001502034,0.00003311429],"category_scores_gemma":[0.0005561056,0.00008534567,0.00008079931,0.0000743723,0.000292334,0.00003266391,0.00001634126,0.0002757211,0.000002356897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000875507,"about_ca_system_score_gemma":0.00009501397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002937365,"about_ca_topic_score_gemma":0.00001677321,"domain_scores_codex":[0.9982712,0.0004462125,0.0006630918,0.0001938846,0.0002817905,0.0001437929],"domain_scores_gemma":[0.9986016,0.0001478676,0.0005245978,0.0001674541,0.00036376,0.0001947855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003952237,0.0001884428,0.1757968,0.00001791357,0.0002014679,0.00001101396,0.0001523493,0.00009232607,0.7857655,0.000006596015,0.000600521,0.03321491],"study_design_scores_gemma":[0.00660204,0.01209622,0.3164513,0.0001046216,0.00006185407,0.000185714,0.0000828688,0.001731351,0.6587008,0.001185482,0.002493717,0.0003040291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963597,0.001966181,0.0003077482,0.001081301,0.00008857679,0.0001342779,0.00000295654,0.000004417897,0.00005483544],"genre_scores_gemma":[0.9942715,0.002172756,0.002297082,0.0005957335,0.0005587296,0.000002888957,0.0000109918,0.00001657344,0.00007371696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1406545,"threshold_uncertainty_score":0.3480295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1121791822479476,"score_gpt":0.3970746762504384,"score_spread":0.2848954940024908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}