{"id":"W4237732428","doi":"10.1172/jci0213359","title":"Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility","year":2002,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Universidad Nacional de La Plata; Heart and Stroke Foundation of Canada; Johns Hopkins University; American Heart Association","keywords":"Contractility; Repolarization; Heart failure; Medicine; Calcium; Heartbeat; Internal medicine; Cardiology; Endocrinology; Biology; Electrophysiology; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003096809,0.0005473254,0.0006083226,0.0003624646,0.000195153,0.0004230264,0.0003110704,0.0005649727,0.001199347],"category_scores_gemma":[0.0001907222,0.0001981173,0.000312911,0.0001406042,0.0004604768,0.0003628439,0.0003761922,0.0009410945,0.0002390706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002504135,"about_ca_system_score_gemma":0.0002090096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001475441,"about_ca_topic_score_gemma":0.0004064552,"domain_scores_codex":[0.999726,0.0000426618,0.00002700324,0.00006240583,0.00007427206,0.00006764005],"domain_scores_gemma":[0.9998581,0.00003210823,0.00004821156,0.00001875852,0.00000985814,0.00003298062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001207378,0.00005580403,0.00006742913,0.00004017505,0.00000660526,0.00004350522,0.00001295722,0.0001052114,0.9956233,0.0003370571,0.00004405395,0.00354323],"study_design_scores_gemma":[0.00006885632,0.001327574,0.0006288541,0.00000908622,0.0000488905,0.0005639237,0.00001659507,0.001295719,0.992214,0.0001114756,0.003706291,0.000008796074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775431,0.002409167,0.01642785,0.000333419,0.0001713166,0.0001509329,0.0001453881,0.0002060301,0.002612829],"genre_scores_gemma":[0.9818865,0.001828425,0.01234824,0.00009413037,0.00004867026,0.0001276744,0.0001361722,0.00003781129,0.00349227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001199347,"threshold_uncertainty_score":0.004012167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1121791822479476,"score_gpt":0.3970746762504384,"score_spread":0.2848954940024908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}