{"id":"W4237757984","doi":"10.21203/rs.3.rs-550445/v2","title":"Endosomal Traffic And Glutamate Synapse Activity Are Increased In VPS35 D620N Mutant Knock-In Mouse Neurons, And Resistant To LRRK2 Kinase Inhibition","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of British Columbia","funders":"Fonds de Recherche du Québec - Santé; Parkinson Canada; Canadian Institutes of Health Research; McGill University; Killam Trusts; Parkinson Society Canada","keywords":"LRRK2; Synapse; Mutant; Endosome; Cell biology; Glutamate receptor; Neuroscience; Chemistry; Biology; Mutation; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001606497,0.0007494796,0.0004315743,0.000680855,0.0002430947,0.0004352141,0.0003302771,0.0006103282,0.001991247],"category_scores_gemma":[0.0001395172,0.0003939774,0.0004110908,0.000198225,0.000475582,0.0003040777,0.0002586564,0.0007420834,0.0005782086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004507223,"about_ca_system_score_gemma":0.0001267456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008772451,"about_ca_topic_score_gemma":0.00120976,"domain_scores_codex":[0.999719,0.00002434563,0.00005353947,0.00008106577,0.00007390884,0.00004821266],"domain_scores_gemma":[0.9997786,0.00001885722,0.00008009004,0.00001724158,0.00001963404,0.00008564052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005711955,0.00001295036,0.00009647445,0.00001498989,0.000005723758,0.00005824163,0.000009888927,0.00001648319,0.9995173,0.00002723277,0.00001578368,0.0001678368],"study_design_scores_gemma":[0.00003379451,0.0002631888,0.009107484,0.00001243962,0.00003418139,0.000899653,0.00004564703,0.0008915237,0.9873734,0.00009607075,0.001234035,0.000008682477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963143,0.0007292114,0.001436934,0.00009575485,0.00002967281,0.00001344451,0.0005935507,0.0001119823,0.0006750956],"genre_scores_gemma":[0.9911007,0.0006709662,0.00250869,0.0001002573,0.00001170071,0.0000581946,0.0009520483,0.00009634912,0.004501048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001991247,"threshold_uncertainty_score":0.006661355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02159029794394023,"score_gpt":0.295200037337016,"score_spread":0.2736097393930758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}