{"id":"W4237835182","doi":"10.1093/neuonc/now212.640","title":"PDTB-21. CD271 (p75NTR) AS A NOVEL DIAGNOSTIC MARKER AND THERAPEUTIC TARGET FOR SHH MEDULLOBLASTOMA","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; Hospital for Sick Children; SickKids Foundation; University of Manitoba","funders":"","keywords":"Medulloblastoma; Cancer research; Gene knockdown; Flow cytometry; Immunohistochemistry; Low-affinity nerve growth factor receptor; Wnt signaling pathway; Progenitor cell; Biology; Sonic hedgehog; Phenotype; Stem cell; Cell culture; Molecular biology; Cell biology; Immunology; Signal transduction; Gene; Receptor; Genetics; Neurotrophin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000924406,0.000230545,0.0002364451,0.0002865764,0.000180651,0.0002747982,0.0002107221,0.0002422966,0.0009988205],"category_scores_gemma":[0.00005204018,0.0001214175,0.0001897798,0.0001954399,0.0001561483,0.0001228327,0.0001676798,0.0005295524,0.0003690147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005843666,"about_ca_system_score_gemma":0.0002993865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001759946,"about_ca_topic_score_gemma":0.003609624,"domain_scores_codex":[0.9999372,0.000007487978,0.000002922942,0.00001105875,0.00002128311,0.00001997133],"domain_scores_gemma":[0.9999851,0.000001613134,0.000003277817,0.000001518542,0.000002477256,0.000006063696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002451944,0.000112053,0.0003859294,0.0001086608,0.00001327961,0.0001788227,0.00002349205,0.0003283268,0.9833643,0.0003556212,0.0007861074,0.01409819],"study_design_scores_gemma":[0.0001709287,0.001300031,0.007301168,0.00001794712,0.0000796937,0.001261129,0.00004201546,0.00263028,0.9552071,0.0001407816,0.03183685,0.00001201106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9634666,0.01920032,0.005742947,0.001074671,0.0001435744,0.0002217891,0.0009106857,0.000297656,0.008941708],"genre_scores_gemma":[0.9805441,0.007994965,0.003640667,0.0002053669,0.00002500953,0.0001041296,0.001173397,0.00002053568,0.006291685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001759946,"threshold_uncertainty_score":0.004239857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01143361407806217,"score_gpt":0.2666764728040845,"score_spread":0.2552428587260223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}