{"id":"W4237850803","doi":"10.22215/etd/2020-14372","title":"Characterizing Aptamer-Based Alpha-Synuclein Fibril Inhibitors as a Potential Therapeutic Agent of Parkinson's Disease","year":2020,"lang":"en","type":"dissertation","venue":"","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Division of Graduate Education; Canadian Institutes of Health Research; Michael J. Fox Foundation for Parkinson's Research","keywords":"Aptamer; Alpha-synuclein; Monomer; Fibril; Chemistry; Oligonucleotide; Biophysics; Biochemistry; Parkinson's disease; Molecular biology; Biology; Disease; Medicine; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001377296,0.0002595472,0.0002496623,0.0001414198,0.0000763042,0.0002834328,0.0001368124,0.0003204281,0.0005622974],"category_scores_gemma":[0.0001119978,0.0001137183,0.0001763427,0.00008193144,0.0000720208,0.0001105773,0.00008918301,0.0002558015,0.0002539358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001835412,"about_ca_system_score_gemma":0.00009932533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001736511,"about_ca_topic_score_gemma":0.0004841877,"domain_scores_codex":[0.9999259,0.00001231673,0.000003871879,0.00001751419,0.00002658585,0.00001395096],"domain_scores_gemma":[0.9999654,0.000007105027,0.000008853283,0.00000214591,0.000009600558,0.000006886703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006660095,0.00004165575,0.00009940278,0.00004968876,0.000005705938,0.00002865906,0.00001041876,0.0002566556,0.9944613,0.00006035071,0.00006455136,0.004855078],"study_design_scores_gemma":[0.00002878706,0.001314909,0.001259609,0.00001261195,0.00002682571,0.0002762212,0.00001099772,0.002439415,0.9893483,0.00005687767,0.005218911,0.000006618656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971457,0.01336818,0.009983328,0.00020641,0.00007739178,0.0001841085,0.000246852,0.0001034933,0.004373278],"genre_scores_gemma":[0.9771219,0.006073637,0.01072981,0.000200938,0.00002781285,0.0001343185,0.0003093351,0.00001509883,0.005387129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005622974,"threshold_uncertainty_score":0.001881123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009412106320618513,"score_gpt":0.2641572831395285,"score_spread":0.25474517681891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}