{"id":"W4237921810","doi":"10.33774/chemrxiv-2021-nk95v-v2","title":"The Total Synthesis of Proposed Immunoactive Glycolipids from S. Pneumoniae and a Re-evaluation of Their Immunological Activity","year":2021,"lang":"en","type":"preprint","venue":"","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Natural Sciences and Engineering Research Council of Canada; Windsor Cancer Centre Foundation; Compute Canada; University of Windsor","keywords":"CD1D; Glycolipid; Ceramide; Glycosphingolipid; Natural killer T cell; Antigen; Biology; Immune system; Receptor; Major histocompatibility complex; Streptococcus pneumoniae; T-cell receptor; Immunology; Cell biology; Biochemistry; Bacteria; T cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001423625,0.0005263838,0.0003768814,0.0001910657,0.0001915439,0.0006537772,0.0003514073,0.0003627894,0.001885467],"category_scores_gemma":[0.0002480744,0.0001768325,0.000615478,0.0002915093,0.0002203184,0.0004780625,0.0002962318,0.0005080907,0.0008398832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004208032,"about_ca_system_score_gemma":0.0005462562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008049039,"about_ca_topic_score_gemma":0.0007727116,"domain_scores_codex":[0.999912,0.0000110786,0.000004344906,0.00002027774,0.00003188081,0.00002055222],"domain_scores_gemma":[0.9999428,0.0000113304,0.00001078343,0.00001112374,0.00001352035,0.0000106219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005387922,0.0001341132,0.00100862,0.001551452,0.00007231566,0.0004521992,0.00009678749,0.03297419,0.9189439,0.006137584,0.0006564649,0.03743369],"study_design_scores_gemma":[0.00005344594,0.0005888643,0.0006346517,0.00004548356,0.00008650058,0.0002382647,0.00005941771,0.02930229,0.9473299,0.001826709,0.0198053,0.00002917696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9498612,0.004710827,0.03295822,0.0002507912,0.0001738784,0.00008472105,0.002044045,0.000301072,0.009615266],"genre_scores_gemma":[0.9305363,0.004355346,0.0577726,0.00006604256,0.00001811327,0.0001058183,0.002071527,0.0001599859,0.004914325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001885467,"threshold_uncertainty_score":0.006307542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02589333964402653,"score_gpt":0.2592877844278145,"score_spread":0.2333944447837879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}