{"id":"W4237943893","doi":"10.1021/ja037289f","title":"Optical Sensors Based on Hybrid Aptamer/Conjugated Polymer Complexes","year":2004,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":506,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Aptamer; Chemistry; Cationic polymerization; Oligonucleotide; Combinatorial chemistry; Conformational change; Conjugated system; Biosensor; DNA; Polymer; Biophysics; Thrombin; Stereochemistry; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003182804,0.0007293514,0.0003845926,0.0005789889,0.0002166017,0.0008960113,0.0008142269,0.0009500653,0.00234494],"category_scores_gemma":[0.0007276308,0.0005813855,0.0002528033,0.0004004654,0.0004419471,0.0008470144,0.0005370951,0.0007385232,0.001215472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005681395,"about_ca_system_score_gemma":0.0001710239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002338882,"about_ca_topic_score_gemma":0.0003240794,"domain_scores_codex":[0.9993939,0.00006410018,0.00002933077,0.0001640897,0.000274764,0.00007385341],"domain_scores_gemma":[0.9996901,0.0001163349,0.00006100023,0.00001878978,0.00006675508,0.00004714146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001117627,0.00005088705,0.0001332514,0.0001245376,0.00002449629,0.00008967946,0.00002575024,0.0005401503,0.9882747,0.0007600925,0.0004754952,0.009389087],"study_design_scores_gemma":[0.00002368235,0.0001300693,0.0003772318,0.000008728284,0.00001742062,0.0002428296,0.00000814438,0.003813632,0.9912525,0.000202578,0.00390958,0.00001369311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7415966,0.01184467,0.217272,0.001014368,0.0008714919,0.0004541402,0.0006878839,0.004884635,0.02137419],"genre_scores_gemma":[0.8860677,0.003384467,0.09180325,0.001101291,0.0001827697,0.0003168691,0.0004306252,0.0001686399,0.01654441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00234494,"threshold_uncertainty_score":0.007844567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007126219957817414,"score_gpt":0.2578966961915898,"score_spread":0.2507704762337724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}